513030 | PD 169316 - CAS 152121-53-4 - Calbiochem

513030
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₀H₁₃FN₄O₂ 152121-53-4

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      513030-1MG
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          Plastic ampoule 1 mg
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          Description
          OverviewA potent, cell-permeable, reversible, competitive, and selective p38 MAP kinase inhibitor (IC50 = 89 nM). Inhibition of p38 MAP kinase by PD 169316 blocks apoptosis induced by trophic factor withdrawal in non-neuronal and neuronal cell lines.
          Catalogue Number513030
          Brand Family Calbiochem®
          Synonyms4-(4-Fluorophenyl)-2-(4-nitrophenyl)-5-(4-pyridyl)-1H-imidazole
          References
          ReferencesNath, R., et al. 2001. Cell Mol. Biol. Lett. 6, 173.
          Gallagher, T.F., et al. 1997. Bioorg. Med. Chem. 5, 49.
          Kummer, J.L., et al. 1997. J. Biol. Chem. 272, 20490.
          Product Information
          CAS number152121-53-4
          ATP CompetitiveY
          FormOrange-yellow solid
          Hill FormulaC₂₀H₁₃FN₄O₂
          Chemical formulaC₂₀H₁₃FN₄O₂
          ReversibleY
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary Targetp38 MAP kinase
          Primary Target IC<sub>50</sub>89 nM against p38 MAP kinase
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          513030

          References

          Reference overview
          Nath, R., et al. 2001. Cell Mol. Biol. Lett. 6, 173.
          Gallagher, T.F., et al. 1997. Bioorg. Med. Chem. 5, 49.
          Kummer, J.L., et al. 1997. J. Biol. Chem. 272, 20490.

          Brochure

          Title
          MAP Kinases Technical Bulletin
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision04-January-2010 RFH
          Synonyms4-(4-Fluorophenyl)-2-(4-nitrophenyl)-5-(4-pyridyl)-1H-imidazole
          DescriptionA potent, cell-permeable, reversible, competitive, and selective p38 MAP kinase inhibitor (IC50= 89 nM). Inhibition of p38 MAP kinase by PD 169316 blocks apoptosis induced by trophic factor withdrawal in non-neuronal and neuronal cell lines.
          FormOrange-yellow solid
          CAS number152121-53-4
          Chemical formulaC₂₀H₁₃FN₄O₂
          Structure formulaStructure formula
          Purity≥98% by HPLC
          SolubilityDMSO (10 mg/ml)
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C.
          Toxicity Standard Handling
          ReferencesNath, R., et al. 2001. Cell Mol. Biol. Lett. 6, 173.
          Gallagher, T.F., et al. 1997. Bioorg. Med. Chem. 5, 49.
          Kummer, J.L., et al. 1997. J. Biol. Chem. 272, 20490.