513033 | PD 168393 - CAS 194423-15-9 - Calbiochem

513033
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₇H₁₃BrN₄O 194423-15-9

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      513033-1MG
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          Plastic ampoule 1 mg
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          Description
          OverviewA potent, cell-permeable, irreversible, ATP-competitive and selective inhibitor of EGF receptor (EGFR) tyrosine kinase activity (IC50 = 700 pM). Does not inhibit other protein kinases. Acts by binding to the catalytic domain of the EGFR with a 1:1 stoichiometry and alkylating Cys773. Excellent antitumor agent in vivo.
          Catalogue Number513033
          Brand Family Calbiochem®
          Synonyms4-[(3-Bromophenyl)amino]-6-acrylamidoquinazoline
          References
          ReferencesFry, D.W., et al. 1998. Proc. Natl. Acad. Sci USA 95, 12022.
          Product Information
          CAS number194423-15-9
          ATP CompetitiveY
          FormYellow solid
          Hill FormulaC₁₇H₁₃BrN₄O
          Chemical formulaC₁₇H₁₃BrN₄O
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          ApplicationPD 168393, CAS 194423-15-9, is a cell-permeable, potent, selective, irreversible, ATP-competitive inhibitor of EGF receptor (EGFR) tyrosine kinase activity (IC50 = 700 pM).
          Biological Information
          Primary TargetEGFR
          Primary Target IC<sub>50</sub>700 pM against EGFR
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. Avoid freeze/thaw cycles of solutions.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          513033

          References

          Reference overview
          Fry, D.W., et al. 1998. Proc. Natl. Acad. Sci USA 95, 12022.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision28-April-2015 JSW
          Synonyms4-[(3-Bromophenyl)amino]-6-acrylamidoquinazoline
          DescriptionA potent, cell-permeable, irreversible, ATP-competitive and selective inhibitor of EGF receptor (EGFR) tyrosine kinase activity (IC50 = 0.70 nM). Does not inhibit other protein kinases. Acts by binding to the catalytic domain of the EGFR with a 1:1 stoichiometry and alkylating Cys773. Excellent antitumor agent in vivo.
          FormYellow solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number194423-15-9
          Chemical formulaC₁₇H₁₃BrN₄O
          Structure formulaStructure formula
          Purity≥98% by HPLC
          SolubilityDMSO (200 mg/ml)
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. Avoid freeze/thaw cycles of solutions.
          Toxicity Standard Handling
          ReferencesFry, D.W., et al. 1998. Proc. Natl. Acad. Sci USA 95, 12022.