234490 | PD 153035 - CAS 153436-54-5 - Calbiochem

234490
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₆H₁₄BrN₃O₂ 153436-54-5

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      234490-1MG
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          Plastic ampoule 1 mg
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          Description
          OverviewAn extremely potent, cell-permeamble, reversible, ATP-competitive and specific inhibitor of the tyrosine kinase activity of the epidermal growth factor receptor (EGFR; IC50 = 25 pM; Ki = 6 pM). Rapidly suppresses autophosphorylation of EGFR at low nanomolar concentrations in fibroblasts or in human epidermoid carcinoma cells. Also selectively blocks EGF-mediated cellular processes including mitogenesis, early gene expression, and oncogenic transformation. A 10 mM (500 µg/139 µl) solution of PD 153035 (Cat. No. 234491) in DMSO is also available.
          Catalogue Number234490
          Brand Family Calbiochem®
          SynonymsAG 1517, 4-[(3-Bromophenyl)amino]-6,7-dimethoxyquinazoline, SU 5271, Compound 32
          References
          ReferencesBridges, A.J., et al. 1996. J. Med. Chem. 39, 267.
          Fry, D.W., et al. 1994. Science 265, 1093.
          Product Information
          CAS number153436-54-5
          ATP CompetitiveY
          DeclarationSold under license of U.S. Patent 5,457,105 and European Patent 0,566,266.
          FormWhite solid
          Hill FormulaC₁₆H₁₄BrN₃O₂
          Chemical formulaC₁₆H₁₄BrN₃O₂
          ReversibleY
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetEGFR
          Primary Target IC<sub>50</sub>25 pM
          Primary Target K<sub>i</sub>6 pM against epidermal growth factor receptor (EGFR)
          Purity≥97% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot and freeze at -20°C. Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          234490

          References

          Reference overview
          Bridges, A.J., et al. 1996. J. Med. Chem. 39, 267.
          Fry, D.W., et al. 1994. Science 265, 1093.

          Citations

          Title
        • Nikolay L. Malinin, et al. (2005) Amyloid-b neurotoxicity is mediated by FISH adapter protein and ADAM12 metalloprotease activity. Proceedings of the National Academy of Sciences (USA) 102, 3058-3063.
        • Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision05-April-2011 RFH
          SynonymsAG 1517, 4-[(3-Bromophenyl)amino]-6,7-dimethoxyquinazoline, SU 5271, Compound 32
          DescriptionAn extremely potent, cell-permeamble, reversible, ATP-competitive and specific inhibitor of the tyrosine kinase activity of the epidermal growth factor receptor (EGFR; IC50 = 25 pM; Ki = 6 pM). Rapidly suppresses autophosphorylation of EGFR at low nanomolar concentrations in fibroblasts or in human epidermoid carcinoma cells. Also selectively blocks EGF-mediated cellular processes including mitogenesis, early gene expression and oncogenic transformation.
          FormWhite solid
          CAS number153436-54-5
          Chemical formulaC₁₆H₁₄BrN₃O₂
          Structure formulaStructure formula
          Purity≥97% by HPLC
          SolubilityDMSO (5 mg/ml)
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot and freeze at -20°C. Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Standard Handling
          ReferencesBridges, A.J., et al. 1996. J. Med. Chem. 39, 267.
          Fry, D.W., et al. 1994. Science 265, 1093.
          Citation
        • Nikolay L. Malinin, et al. (2005) Amyloid-b neurotoxicity is mediated by FISH adapter protein and ADAM12 metalloprotease activity. Proceedings of the National Academy of Sciences (USA) 102, 3058-3063.