513022 | PD 150606 - CAS 426821-41-2 - Calbiochem

513022
Price could not be retrieved
Minimum Quantity needs to be mulitiple of
Upon Order Completion More Information
You Saved ()
 
Request Pricing
Limited AvailabilityLimited Availability
Stocked 
Discontinued
Limited Quantities Available
Available
    Remaining : Will advise
      Remaining : Will advise
      Will advise
      Contact Customer Service
      View Pricing & Availability
      Click To Print This Page

      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₉H₇IO₂S 426821-41-2

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      513022-5MG
      Retrieving availability...
      Limited AvailabilityLimited Availability
      Stocked 
      Discontinued
      Limited Quantities Available
      Available
        Remaining : Will advise
          Remaining : Will advise
          Will advise
          Contact Customer Service

          Plastic ampoule 5 mg
          Retrieving price...
          Price could not be retrieved
          Minimum Quantity needs to be mulitiple of
          Upon Order Completion More Information
          You Saved ()
           
          Request Pricing
          Description
          OverviewA cell-permeable, non-competitive, selective non-peptide calpain inhibitor [Ki = 210 nM for calpain-1 (Cat. Nos. 208712 and 208713) and 370 nM for calpain-2 (Cat. Nos. 208715 and 208718)] directed towards the calcium binding sites of calpain. Exhibits high specificity for calpains relative to other proteases, such as cathepsin B and cathepsin L. Does not shield calpain against inactivation by the active-site inhibitor trans-(epoxysuccinyl)-L-leucyl-amido-3-methylbutane. Reportedly prevents dexamethasone-induced apoptosis in thymocytes.
          Catalogue Number513022
          Brand Family Calbiochem®
          Synonyms3-(4-Iodophenyl)-2-mercapto-(Z)-2-propenoic Acid
          References
          ReferencesLin, G.D., et al. 1997. Nat. Struct. Biol. 4, 539.
          Squier, M.K., and Cohen, J.J. 1997. J. Immunol. 158, 3960.
          Edelstein, C.L., et al. 1996. Kidney Int. 50, 1150.
          Wang, K.K.W., et al. 1996. Proc. Natl. Acad. Sci. USA 93, 6687.
          Product Information
          CAS number426821-41-2
          ATP CompetitiveN
          FormOff-white solid
          Hill FormulaC₉H₇IO₂S
          Chemical formulaC₉H₇IO₂S
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetCalpain-1
          Primary Target K<sub>i</sub>210 nM for calpain-1 and 370 nM for calpain-2
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          513022

          References

          Reference overview
          Lin, G.D., et al. 1997. Nat. Struct. Biol. 4, 539.
          Squier, M.K., and Cohen, J.J. 1997. J. Immunol. 158, 3960.
          Edelstein, C.L., et al. 1996. Kidney Int. 50, 1150.
          Wang, K.K.W., et al. 1996. Proc. Natl. Acad. Sci. USA 93, 6687.

          Brochure

          Title
          Calcium Metabolism and Related Products Brochure

          Citations

          Title
        • Ping Han, et al. (2005) Suppression of Cyclin-Dependent Kinase 5 Activation by Amyloid Precursor Protein: A Novel Excitoprotective Mechanism Involving Modulation of Tau Phosphorylation. Journal of Neuroscience 25, 11542-11552.
        • Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision15-April-2011 RFH
          Synonyms3-(4-Iodophenyl)-2-mercapto-(Z)-2-propenoic Acid
          DescriptionA cell-permeable, selective non-peptide calpain inhibitor (Ki = 210 nM for calpain I and 370 nM for calpain II) directed towards the calcium- binding sites of calpain. Exhibits high specificity for calpains relative to other proteases, such as cathepsin B and L. PD 150606 is a non-competitive inhibitor with respect to the substrate and does not shield calpain against inactivation by the active-site inhibitor trans-(epoxysuccinyl)-L-leucyl-amido-3-methylbutane. Reportedly prevents dexamethasone-induced apoptosis of thymocytes.
          FormOff-white solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number426821-41-2
          Chemical formulaC₉H₇IO₂S
          Structure formulaStructure formula
          Purity≥95% by HPLC
          SolubilityDMSO (100 mg/ml) or Methanol (25 mg/ml)
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
          Toxicity Standard Handling
          ReferencesLin, G.D., et al. 1997. Nat. Struct. Biol. 4, 539.
          Squier, M.K., and Cohen, J.J. 1997. J. Immunol. 158, 3960.
          Edelstein, C.L., et al. 1996. Kidney Int. 50, 1150.
          Wang, K.K.W., et al. 1996. Proc. Natl. Acad. Sci. USA 93, 6687.
          Citation
        • Ping Han, et al. (2005) Suppression of Cyclin-Dependent Kinase 5 Activation by Amyloid Precursor Protein: A Novel Excitoprotective Mechanism Involving Modulation of Tau Phosphorylation. Journal of Neuroscience 25, 11542-11552.