506274 PACOCF₃ - CAS 141022-99-3 - Calbiochem

506274
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₇H₃₁F₃O 141022-99-3

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      506274-5MG
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          Plastic ampoule 5 mg
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          Description
          OverviewA novel Ca2+-independent and reversible inhibitor of phospholipase A2 (PLA2; IC50 = 3.8 µM). May also inhibit Ca2+-dependent PLA2 at much higher concentrations (IC50 = 45 µM).
          Catalogue Number506274
          Brand Family Calbiochem®
          SynonymsPalmitoyl Trifluoromethyl Ketone
          References
          ReferencesConde-Frieboes, K., et al. 1996. J. Am. Chem. Soc. 118, 5519.
          Lio, Y.C., et al. 1996. Biochim. Biophys. Acta 1302, 55.
          Ackermann, E.J., et al. 1995. J. Biol. Chem. 270, 445.
          Product Information
          CAS number141022-99-3
          ATP CompetitiveN
          FormLiquid
          FormulationIn ethanol.
          Hill FormulaC₁₇H₃₁F₃O
          Chemical formulaC₁₇H₃₁F₃O
          ReversibleY
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetPLA₂
          Primary Target IC<sub>50</sub>3.8 µM and 45 µM against phospholipase A2 (PLA2) and Ca2+-dependent PLA2, respectively.
          Purity≥97% by TLC
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped with Blue Ice or with Dry Ice
          Toxicity Standard Handling
          Storage -20°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution in DMSO, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C. Product has a very low melting point. The product will change from a solid to a liquid if held in your hand or kept at room temperature or warmer for any period of time. It is best to keep the product cool while in use by placing it in the refrigerator or on ice during experimentation. Once diluted in buffer, do not store in aqueous solutions for >1 day.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          506274

          References

          Reference overview
          Conde-Frieboes, K., et al. 1996. J. Am. Chem. Soc. 118, 5519.
          Lio, Y.C., et al. 1996. Biochim. Biophys. Acta 1302, 55.
          Ackermann, E.J., et al. 1995. J. Biol. Chem. 270, 445.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision15-April-2011 RFH
          SynonymsPalmitoyl Trifluoromethyl Ketone
          DescriptionA novel Ca2+-independent phospholipase A2 inhibitor (IC50 = 3.8 µM). May also inhibit Ca2+-dependent phospholipase A2 at higher concentrations (IC50 = 45 µM)
          FormLiquid
          FormulationIn ethanol.
          CAS number141022-99-3
          Chemical formulaC₁₇H₃₁F₃O
          Structure formulaStructure formula
          Purity≥97% by TLC
          SolubilitySupplied as a solution in ethanol. To change the solvent, evaporate the ethanol with a stream of nitrogen and immediately reconstitute with the solvent of choice. Soluble in DMSO (30 mg/ml). Only minimally soluble in aqueous buffers; do not use basic buffers; unstable at basic pH.
          Storage -20°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution in DMSO, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C. Product has a very low melting point. The product will change from a solid to a liquid if held in your hand or kept at room temperature or warmer for any period of time. It is best to keep the product cool while in use by placing it in the refrigerator or on ice during experimentation. Once diluted in buffer, do not store in aqueous solutions for >1 day.
          Toxicity Standard Handling
          ReferencesConde-Frieboes, K., et al. 1996. J. Am. Chem. Soc. 118, 5519.
          Lio, Y.C., et al. 1996. Biochim. Biophys. Acta 1302, 55.
          Ackermann, E.J., et al. 1995. J. Biol. Chem. 270, 445.