497985 | Ornithine Decarboxylase Inhibitor, POB - Calbiochem

497985
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₁₉H₃₁N₃O₆

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      497985-10MG
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          Glass bottle 10 mg
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          Description
          OverviewA cell-permeable pyridoxyl-ornithine compound that acts as an effective analog of the transition state coenzyme-substrate adduct during orthithine decarboxylase- (ODC) catalyzed conversion of L-orthithine to Pultrescine. POB is typically 5- to 10-fold more potent than DFMO (Cat. No. 288500) in inhibiting intracellular ODC activity and tumor cell growth in cultures, while exhibiting little effect against the growth of nontumorigenic human aortic smooth muscle cells.
          Catalogue Number497985
          Brand Family Calbiochem®
          SynonymsN-(4ʹ-Pyridoxyl)-Ornithine(BOC)-OMe, ODC Inhibitor, POB
          References
          ReferencesWu, F., et al. 2007. Mol. Cancer Ther. 6, 1831.
          Product Information
          FormWhite to off-white solid
          FormulationSupplied as a hydrochloride salt.
          Hill FormulaC₁₉H₃₁N₃O₆
          Chemical formulaC₁₉H₃₁N₃O₆
          Hygroscopic Hygroscopic
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Purity≥95% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          497985

          References

          Reference overview
          Wu, F., et al. 2007. Mol. Cancer Ther. 6, 1831.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision26-July-2018 JSW
          SynonymsN-(4ʹ-Pyridoxyl)-Ornithine(BOC)-OMe, ODC Inhibitor, POB
          DescriptionA cell-permeable pyridoxyl-ornithine compound that acts as an effective analog of the transition state coenzyme-substrate adduct during orthithine decarboxylase- (ODC) catalyzed conversion of L-orthithine to Pultrescine. POB is typically 5- to 10-fold more potent than DFMO (Cat. No. 288500) in inhibiting intracellular ODC activity and tumor cell growth in cultures, while exhibiting little effect against the growth of nontumorigenic human aortic smooth muscle cells.
          FormWhite to off-white solid
          FormulationSupplied as a hydrochloride salt.
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₁₉H₃₁N₃O₆
          Structure formulaStructure formula
          Purity≥95% by HPLC
          SolubilityH₂O (1 mg/ml)
          Storage +2°C to +8°C
          Hygroscopic
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesWu, F., et al. 2007. Mol. Cancer Ther. 6, 1831.