495621 | Olomoucine II - CAS 500735-47-7 - Calbiochem

495621
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₉H₂₆N₆O₂ 500735-47-7

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      495621-5MG
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          Plastic ampoule 5 mg
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          Description
          OverviewA cell-permeable 2,6,9-trisubstituted purine analog that acts as a potent, reversible, and ATP-competitive inhibitor of Cdk1/B with an IC50 of 20 nM and displays increased potency over purvalanol A (Cat. No. 540500; IC50 = 50 nM), Roscovitine (Cat. No. 557360; IC50 = 450 nM), Bohemine (Cat. No. 203600; IC50 = 1.1 µM) and Olomoucine (Cat. No. 495620; IC50 = 7.0 µM). Further, exerts greater in vitro cytotoxicity in various cancer cell lines (IC50 = 3.0 µM, 5.3 µM, 6.3 µM, 6.3 µM and 11.1 µM for CEM, MCF7, HOS, G631 and K562, respectively).
          Catalogue Number495621
          Brand Family Calbiochem®
          Synonyms6-(2-Hydroxybenzylamino)-2-((1R)-(hydroxymethyl)propyl)amino)-9-isopropylpurine
          References
          ReferencesKrystof, V., et al. 2002. Bioorg. Med. Chem. Lett. 12, 3283.
          Product Information
          CAS number500735-47-7
          ATP CompetitiveY
          FormColorless solid
          Hill FormulaC₁₉H₂₆N₆O₂
          Chemical formulaC₁₉H₂₆N₆O₂
          ReversibleY
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetCdk1/B
          Primary Target IC<sub>50</sub>20 nM against Cdk1/B
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          495621

          References

          Reference overview
          Krystof, V., et al. 2002. Bioorg. Med. Chem. Lett. 12, 3283.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision01-April-2011 RFH
          Synonyms6-(2-Hydroxybenzylamino)-2-((1R)-(hydroxymethyl)propyl)amino)-9-isopropylpurine
          DescriptionA cell-permeable, potent, reversible, and ATP-competitive inhibitor of Cdk1/cyclin B (IC50 = 20 nM) that displays increased potency over purvalanol A (Cat. No. 540500; IC50 = 50 nM), Roscovitine (Cat. No. 557360; IC50 = 450 nM), Bohemine (Cat. No. 203600; IC50 = 1.1 µM), and Olomoucine (Cat. No. 495620; IC50 = 7.0 µM). Also exhibits greater in vitro cytotoxicity in various cancer cell lines (IC50 = 3.0 µM, 5.3 µM, 6.3 µM, 6.3 µM, and 11.1 µM for CEM, MCF7, HOS, G631, and K562, respectively).
          FormColorless solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number500735-47-7
          Chemical formulaC₁₉H₂₆N₆O₂
          Structure formulaStructure formula
          Purity≥95% by HPLC
          SolubilityDMSO (1 mg/ml) or Ethanol (1 mg/ml)
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Standard Handling
          ReferencesKrystof, V., et al. 2002. Bioorg. Med. Chem. Lett. 12, 3283.