495620 Olomoucine - CAS 101622-51-9 - Calbiochem

495620
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₅H₁₈N₆O 101622-51-9

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      495620-1MG
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          Plastic ampoule 1 mg
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          495620-5MG
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              Plastic ampoule 5 mg
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              Description
              OverviewA purine derivative that acts as a potent, reversible and selective inhibitor of p34cdk1/cyclin B (IC50 = 7 µM) and related kinases including p33cdk2/cyclin A (IC50 = 7 µM), p33cdk2/cyclin E (IC50 = 7 µM), p33cdk5/p35 (IC50 = 3 µM), and p44 MAP kinase (IC50 = 25 µM). Acts by competing for the ATP binding domain of the kinase. Exhibits reduced sensitivity towards related kinases, p34cdk4/cyclin D (IC50 > 1 mM), and p40cdk6/cyclin D3 (IC50 > 250 µM). Does not significantly affect the activity of other protein kinases at 1 mM. Known to inhibit DNA synthesis in interleukin-2-stimulated T lymphocytes and trigger G1 arrest similar to that observed in interleukin-2-deprived cells. Also used to synchronize cells in G1. A 50 mM (5 mg/336 µl) solution of Olomoucine (Cat. No. 495624) in DMSOis also available.
              Catalogue Number495620
              Brand Family Calbiochem®
              SynonymsOlomoucine
              References
              ReferencesAbraham, R.T., et al. 1995. Biol. Cell 83, 105.
              Mistelli, T., and Warren, G. 1995. J. Cell Sci. 108, 2715.
              Glab, N., et al. 1994. FEBS Lett. 353, 207.
              Veselý, J., et al. 1994. Eur. J. Biochem. 224, 771.
              Product Information
              CAS number101622-51-9
              ATP CompetitiveY
              FormCrystalline solid
              Hill FormulaC₁₅H₁₈N₆O
              Chemical formulaC₁₅H₁₈N₆O
              ReversibleY
              Structure formula ImageStructure formula Image
              Applications
              Biological Information
              Primary Targetp34cdk1/cyclin B
              Primary Target IC<sub>50</sub>7 µM, 7 µM, 7 µM, 3 µM, 25 µM against p34cdk1/cyclin B, p33cdk2/cyclin A, p33cdk2/cyclin E, p33cdk5/p35, and p44 MAP kinase, respectively
              Purity≥98% by TLC
              Physicochemical Information
              Cell permeableY
              Dimensions
              Materials Information
              Toxicological Information
              Safety Information according to GHS
              Safety Information
              Product Usage Statements
              Storage and Shipping Information
              Ship Code Ambient Temperature Only
              Toxicity Standard Handling
              Storage -20°C
              Do not freeze Ok to freeze
              Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). DMSO stock solutions are stable for up to 6 months at -20°C.
              Packaging Information
              Transport Information
              Supplemental Information
              Specifications

              Documentation

              SDS

              Title

              Safety Data Sheet (SDS) 

              Certificates of Analysis

              TitleLot Number
              495620

              References

              Reference overview
              Abraham, R.T., et al. 1995. Biol. Cell 83, 105.
              Mistelli, T., and Warren, G. 1995. J. Cell Sci. 108, 2715.
              Glab, N., et al. 1994. FEBS Lett. 353, 207.
              Veselý, J., et al. 1994. Eur. J. Biochem. 224, 771.

              Brochure

              Title
              MAP Kinases Technical Bulletin
              Data Sheet

              Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

              Revision26-April-2018 JSW
              SynonymsOlomoucine
              DescriptionA purine derivative that acts as a potent, reversible, and selective inhibitor of p34cdc2/cyclin B (IC50 = 7 µM) and related kinases, including p33cdk2/cyclin A (IC50 = 7 µM), p33cdk2/cyclin E (IC50 = 7 µM), p33cdk5/p35 (IC50 = 3 µM), and p44MAPK (IC50 = 25 µM). Acts by competing for the ATP binding domain of the kinase. Exhibits reduced sensitivity towards related kinases, p34cdk4/cyclin D1 (IC50 > 1000 µM) and p40cdk6/cyclin D3 (IC50 > 250 µM). Does not significantly affect the activity of other protein kinases even at 1 mM concentrations. Known to inhibit DNA synthesis in interleukin-2 stimulated T lymphocytes and triggers G1 arrest similar to that observed in interleukin-2 deprived cells. Also used to synchronize cells in G1.
              FormCrystalline solid
              CAS number101622-51-9
              Chemical formulaC₁₅H₁₈N₆O
              Structure formulaStructure formula
              Purity≥98% by TLC
              SolubilityDMSO
              Storage -20°C
              Do Not Freeze Ok to freeze
              Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). DMSO stock solutions are stable for up to 6 months at -20°C.
              Toxicity Standard Handling
              ReferencesAbraham, R.T., et al. 1995. Biol. Cell 83, 105.
              Mistelli, T., and Warren, G. 1995. J. Cell Sci. 108, 2715.
              Glab, N., et al. 1994. FEBS Lett. 353, 207.
              Veselý, J., et al. 1994. Eur. J. Biochem. 224, 771.