494128 | Ochratoxin A - CAS 303-47-9 - Calbiochem

494128
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₀H₁₈ClNO₆ 303-47-9

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      494128-1MG
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          Glass bottle 1 mg
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          Description
          OverviewOchratoxin A (OTA) is a mycotoxin that acts through mechanisms such as the inhibition of protein synthesis, and may also be mediated by organic anion transporters (OATs). OTA is indicated to play a role in down-regulating the expression of protective enzymes against oxidative stress. It is known to accumulate in several tissues of the body but is primarily localized in the kidney where it impairs proximal tubular functions, and thereby causes nephrotoxicity, glucosuria, enzymuria, and a decrease in the transport of para-aminohippuric acid (PAH). It also acts as an immunosuppressant and as a potent teratogen and carcinogen.
          Catalogue Number494128
          Brand Family Calbiochem®
          SynonymsOchratoxin A, Aspergillus ochraceus, OTA
          References
          ReferencesAnzai, N., et al. 2010. Toxins 2, 1381.
          Chopra, M., et al. 2010. Cell Biol. Toxicol. 26, 239.
          Luhe, A., et al. 2002. Tox. Sci. 73, 315.
          Dirheimer, G., et al. 1991. IARC Swci Publ. 115, 171.
          Product Information
          CAS number303-47-9
          FormOff-white powder
          Hill FormulaC₂₀H₁₈ClNO₆
          Chemical formulaC₂₀H₁₈ClNO₆
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Purity≥97% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          R PhraseR: 28-38-60-61

          Very toxic if swallowed.
          Irritating to skin.
          May impair fertility.
          May cause harm to the unborn child.
          S PhraseS: 24/25-36/37/39-45

          Avoid contact with skin and eyes.
          Wear suitable protective clothing, gloves and eye/face protection.
          In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Highly Toxic & Carcinogenic / Teratogenic
          Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          494128

          References

          Reference overview
          Anzai, N., et al. 2010. Toxins 2, 1381.
          Chopra, M., et al. 2010. Cell Biol. Toxicol. 26, 239.
          Luhe, A., et al. 2002. Tox. Sci. 73, 315.
          Dirheimer, G., et al. 1991. IARC Swci Publ. 115, 171.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision11-October-2016 JSW
          SynonymsOchratoxin A, Aspergillus ochraceus, OTA
          DescriptionOchratoxin A (OTA) is a mycotoxin that acts through mechanisms such as the inhibition of protein synthesis, and may also be mediated by organic anion transporters (OATs). OTA is indicated to play a role in down-regulating the expression of protective enzymes against oxidative stress. It is known to accumulate in several tissues of the body but is primarily localized in the kidney where it impairs proximal tubular functions, and thereby causes nephrotoxicity, glucosuria, enzymuria, and a decrease in the transport of para-aminohippuric acid (PAH). It also acts as an immunosuppressant and as a potent teratogen and carcinogen.
          FormOff-white powder
          Intert gas (Yes/No) Packaged under inert gas
          CAS number303-47-9
          Chemical formulaC₂₀H₁₈ClNO₆
          Structure formulaStructure formula
          Purity≥97% by HPLC
          SolubilityDMSO (50 mg/ml; nearly colorless solution)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Highly Toxic & Carcinogenic / Teratogenic
          ReferencesAnzai, N., et al. 2010. Toxins 2, 1381.
          Chopra, M., et al. 2010. Cell Biol. Toxicol. 26, 239.
          Luhe, A., et al. 2002. Tox. Sci. 73, 315.
          Dirheimer, G., et al. 1991. IARC Swci Publ. 115, 171.