499635 | OSC Inhibitor, Ro 48-8071 - CAS 189197-69-1 - Calbiochem

499635
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₃H₂₇BrFNO₂• C₄H₄O₄ 189197-69-1

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      499635-10MG
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          Glass bottle 10 mg
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          Description
          OverviewAn orally bioavailable benzofuranylallylamine compound that acts as a potent, active site targeting, competitive and reversible inhibitor of 2,3-oxidosqualene:lanosterol cyclase activity (OSC; IC50 ~ 6.5 nM against mammalian) and reduces cholesterol synthesis (IC50 ~ 1.5 nM in HepG2 cells) with minimal buildup of both dioxidosqualene and monooxidosqualene. Downregulates 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase mRNA and synthesis, and exerts less adverse effects in animal models than Statins. Shown to preferentially enhance the DNA-binding affinity of mutant p53 and arrest the growth of human breast cancer cells (IC50 ~ 10 µM).
          Catalogue Number499635
          Brand Family Calbiochem®
          Synonyms4ʹ-(6-(Allylmethylamino)hexyloxy)-4-bromo-2ʹ-fluorobenzophenone, fumarate
          References
          ReferencesThoma, R., et al. 2004. Nature 432, 118.
          Peffley, D.M., et al. 1998. Biochem. Pharmacol. 56, 439.
          Morand, O.H., et al. 1997. J. Lipid Res. 38, 373.
          Product Information
          CAS number189197-69-1
          FormOff-white solid
          Hill FormulaC₂₃H₂₇BrFNO₂• C₄H₄O₄
          Chemical formulaC₂₃H₂₇BrFNO₂• C₄H₄O₄
          Hygroscopic Hygroscopic
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Purity≥95% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
          Toxicity Regulatory Review
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          499635

          References

          Reference overview
          Thoma, R., et al. 2004. Nature 432, 118.
          Peffley, D.M., et al. 1998. Biochem. Pharmacol. 56, 439.
          Morand, O.H., et al. 1997. J. Lipid Res. 38, 373.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision04-November-2011 RFH
          Synonyms4ʹ-(6-(Allylmethylamino)hexyloxy)-4-bromo-2ʹ-fluorobenzophenone, fumarate
          DescriptionAn orally bioavailable benzofuranylallylamine compound that acts as a potent, active site targeting, competitive and reversible inhibitor of 2,3-oxidosqualene:lanosterol cyclase activity (OSC; IC50 ~6.5 nM against mammalian) and reduces cholesterol synthesis (IC50 ~1.5 nM in HepG2 cells) with minimal buildup of both dioxidosqualene and monooxidosqualene. Downregulates 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase mRNA and synthesis, and exerts less adverse effects in animal models than Statins. Shown to preferentially enhance the DNA-binding affinity of mutant p53 and arrest the growth of human breast cancer cells (IC50 ~10 µM).
          FormOff-white solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number189197-69-1
          Chemical formulaC₂₃H₂₇BrFNO₂• C₄H₄O₄
          Structure formulaStructure formula
          Purity≥95% by HPLC
          SolubilityH₂O (5 mg/ml)
          Storage +2°C to +8°C
          Hygroscopic
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Regulatory Review
          ReferencesThoma, R., et al. 2004. Nature 432, 118.
          Peffley, D.M., et al. 1998. Biochem. Pharmacol. 56, 439.
          Morand, O.H., et al. 1997. J. Lipid Res. 38, 373.