533087 Niclosamide Ethanolamine - Calbiochem

Niclosamide Ethanolamine, NEN, AMPK activator

Niclosamide Ethanolamine - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: NEN

533087
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₁₃H₈Cl₂N₂O₄·C₂H₇NO

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      5.33087.0001
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          		 Glass bottle 25 mg
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          Description
          OverviewA cell permeable, orally bioavailable, non-toxic salt form of niclosamide that acts as a reversible, mild uncoupler of mitochondria to reduce cellular energy efficiency and increase lipid oxidation. Also shown to reduce the mitochondrial membrane potential in live cells (~ 500 nM). Following oral uptake, it is distributed primarily in the liver. Improves glycemic control, improves insulin sensitivity,and reduces the level of glycated hemoglobin in C57BL/6J mice fed high fat diets. Retards the decline of plasma insulin level in db/db mice and improves their glycemic control. (150 mg/kg., p.o.). Activates AMPK and increases acetyl-CoA carboxylase phosphorylation, but does not affect the activity of gluconeogenic enzymes in the liver. Reported to reduce intracellular lipid accumulation in mice fed high fat diets.
          Catalogue Number533087
          Brand Family Calbiochem®
          SynonymsNEN
          References
          ReferencesTao, H., et al. 2014. Nat. Med. 20, 1263.
          Product Information
          FormYellow solid
          Hill FormulaC₁₃H₈Cl₂N₂O₄·C₂H₇NO
          Chemical formulaC₁₃H₈Cl₂N₂O₄·C₂H₇NO
          ReversibleY
          Applications
          Biological Information
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Niclosamide Ethanolamine - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          References

          Reference overview
          Tao, H., et al. 2014. Nat. Med. 20, 1263.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision01-March-2016 JSW
          SynonymsNEN
          DescriptionA cell permeable, orally bioavailable, non-toxic salt form of niclosamide that acts as a reversible, mild uncoupler of mitochondria to reduce cellular energy efficiency and increase lipid oxidation. Also shown to reduce the mitochondrial membrane potential in live cells (~ 500 nM). Following oral uptake, it is distributed primarily in the liver. Improves glycemic control, improves insulin sensitivity,and reduces the level of glycated hemoglobin in C57BL/6J mice fed high fat diets. Retards the decline of plasma insulin level in db/db mice and improves their glycemic control. (150 mg/kg., p.o.). Activates AMPK and increases acetyl-CoA carboxylase phosphorylation, but does not affect the activity of gluconeogenic enzymes in the liver. Reported to reduce intracellular lipid accumulation in mice fed high fat diets.
          FormYellow solid
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₁₃H₈Cl₂N₂O₄·C₂H₇NO
          Purity≥98% by HPLC
          SolubilityDMSO (50 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesTao, H., et al. 2014. Nat. Med. 20, 1263.