480743 | Neuronal Differentiation Inducer III - CAS 832115-62-5 - Calbiochem

480743
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₁H₁₀N₂O₂S 832115-62-5

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      480743-10MG
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          Plastic ampoule 10 mg
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          Description
          OverviewA cell-permeable isoxazole compound that selectively induces robust neuronal differentiation (Effective concentration = 20 µM) in various stem/progenitor cells. Induces insulin expression, and activates ERK signaling and histone acetylation in MIN6 pancreatic β cells. The underlying excitation-neurogenesis signaling is comprised of, at least in part, an initial NMDA receptor- and L-type chanenels-mediated Ca2+ influx, followed by an activation of CaMKII, phosphorylation/nuclear export of the MEF2 repressor HDAC5, the subsequent de-repression of MEF2, and the eventual activation of the HDAC-MEF2 epigenetic/transcriptional regulatory network.
          Catalogue Number480743
          Brand Family Calbiochem®
          SynonymsN-Cyclopropyl-5-(thiophen-2-yl)isoxazole-3-carboxamide, Isx
          References
          ReferencesDioum, E.M., et al. 2011. Proc. Natl. Acad. Sci. USA 108, 20713.
          Zhang, L., et al. 2011. Differentiation 81, 233.
          Sadek, H., et al. 2008. Proc. Natl. Acad. Sci. USA 105, 6063.
          Schneider, J.W., et al. 2008. Nat. Chem. Biol. 4, 408.
          Product Information
          CAS number832115-62-5
          FormOff-white solid
          Hill FormulaC₁₁H₁₀N₂O₂S
          Chemical formulaC₁₁H₁₀N₂O₂S
          Applications
          Biological Information
          Purity≥95% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          480743

          References

          Reference overview
          Dioum, E.M., et al. 2011. Proc. Natl. Acad. Sci. USA 108, 20713.
          Zhang, L., et al. 2011. Differentiation 81, 233.
          Sadek, H., et al. 2008. Proc. Natl. Acad. Sci. USA 105, 6063.
          Schneider, J.W., et al. 2008. Nat. Chem. Biol. 4, 408.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision21-June-2013 JSW
          SynonymsN-Cyclopropyl-5-(thiophen-2-yl)isoxazole-3-carboxamide, Isx
          DescriptionA cell-permeable isoxazole compound that selectively induces robust neuronal differentiation (Effective concentration = 20 µM) in various stem/progenitor cells. Induces insulin expression, and activates ERK signaling and histone acetylation in MIN6 pancreatic β cells. The underlying excitation-neurogenesis signaling is comprised of, at least in part, an initial NMDA receptor- and L-type chanenels-mediated Ca2+ influx, followed by an activation of CaMKII, phosphorylation/nuclear export of the MEF2 repressor HDAC5, the subsequent de-repression of MEF2, and the eventual activation of the HDAC-MEF2 epigenetic/transcriptional regulatory network.
          FormOff-white solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number832115-62-5
          Chemical formulaC₁₁H₁₀N₂O₂S
          Purity≥95% by HPLC
          SolubilityDMSO (5 mg/ml) or Ethanol (3 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesDioum, E.M., et al. 2011. Proc. Natl. Acad. Sci. USA 108, 20713.
          Zhang, L., et al. 2011. Differentiation 81, 233.
          Sadek, H., et al. 2008. Proc. Natl. Acad. Sci. USA 105, 6063.
          Schneider, J.W., et al. 2008. Nat. Chem. Biol. 4, 408.