567500 Na+/H+ Exchanger Isoform-1 Inhibitor - CAS 861218-38-4 - Calbiochem

567500
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₁H₈N₄OS • CH₃SO₃H 861218-38-4

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      567500-5MG
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          Glass bottle 5 mg
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          Description
          OverviewA cell-permeable acylguanidine compound that inhibits NHE-1-meidated pH recovery after acidosis in PS120 cells (IC50 = 2.0 µM). Shown exhibit cardioprotective efficacy both in an isolated rat heart ischemia model in vitro and in a rat myocardial infarction model in vivo.
          Catalogue Number567500
          Brand Family Calbiochem®
          Synonyms(4-Cyanobenzo[b]thiophene-2-carbonyl)guanidine, methanesulfonate, NHE-1 Inhibitor
          References
          ReferencesLee, S., et al. 2005. Bioorg. Med. Chem. Lett. 15, 2998.
          Product Information
          CAS number861218-38-4
          ATP CompetitiveN
          FormYellow solid
          Hill FormulaC₁₁H₈N₄OS • CH₃SO₃H
          Chemical formulaC₁₁H₈N₄OS • CH₃SO₃H
          Hygroscopic Hygroscopic
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetInhibits NHE-1-meidated pH recovery after acidosis
          Primary Target IC<sub>50</sub>2.0 µM against NHE-1
          Purity≥97% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Harmful
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Na+/H+ Exchanger Isoform-1 Inhibitor - CAS 861218-38-4 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          Na+/H+ Exchanger Isoform-1 Inhibitor - CAS 861218-38-4 - Calbiochem Certificates of Analysis

          TitleLot Number
          567500

          References

          Reference overview
          Lee, S., et al. 2005. Bioorg. Med. Chem. Lett. 15, 2998.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision19-April-2011 RFH
          Synonyms(4-Cyanobenzo[b]thiophene-2-carbonyl)guanidine, methanesulfonate, NHE-1 Inhibitor
          DescriptionA cell-permeable acylguanidine compound that inhibits NHE-1-meidated pH recovery after acidosis in PS120 cells (IC50 = 2.0 µM). Shown exhibit cardioprotective efficacy both in an isolated rat heart ischemia model in vitro and in a rat myocardial infarction model in vivo.
          FormYellow solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number861218-38-4
          Chemical formulaC₁₁H₈N₄OS • CH₃SO₃H
          Structure formulaStructure formula
          Purity≥97% by HPLC
          SolubilityDMSO (100 mg/ml)
          Storage +2°C to +8°C
          Hygroscopic
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months.
          Toxicity Harmful
          ReferencesLee, S., et al. 2005. Bioorg. Med. Chem. Lett. 15, 2998.