492035 | NSC 721648 - CAS 872726-44-8 - Calbiochem

492035
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₅H₁₂FNO₂S 872726-44-8

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      492035-5MG
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          Plastic ampoule 5 mg
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          Description
          OverviewA cell-permeable benzothiazole compound that exhibits potent in vitro antiproliferative activity against HCC 2998, IGROV1, MCF-7, MDA 468, SR, and T-47D (GI50 <1 nM), while showing much reduced effect against 50 other human tumor cells in a panel screening. Although it is a high affinity AhR ligand (IC50 = 25 nM; Ki = 6.8 nM in a TCDD competitive binding study) and a known CYP1A1 inducer, neither property can fully account for its antitumor activity.
          Catalogue Number492035
          Brand Family Calbiochem®
          Synonyms5-Fluoro-2-(3,4-dimethoxyphenyl)benzothiazole, GW 610; PMX 610
          References
          ReferencesAiello, S., et al. 2008. J. Med. Chem. 51, 5135.
          Mortimer, C.G., et al. 2006. J. Med. Chem. 49, 179.
          Product Information
          CAS number872726-44-8
          FormWhite crystalline solid
          Hill FormulaC₁₅H₁₂FNO₂S
          Chemical formulaC₁₅H₁₂FNO₂S
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Purity≥97% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          492035

          References

          Reference overview
          Aiello, S., et al. 2008. J. Med. Chem. 51, 5135.
          Mortimer, C.G., et al. 2006. J. Med. Chem. 49, 179.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision26-January-2009 RFH
          Synonyms5-Fluoro-2-(3,4-dimethoxyphenyl)benzothiazole, GW 610; PMX 610
          DescriptionA cell-permeable benzothiazole compound that exhibits potent in vitro antiproliferative activity against HCC 2998, IGROV1, MCF-7, MDA 468, SR, and T-47D (GI50 <1 nM), while showing much reduced effect against 50 other human tumor cells in a panel screening. Although it is a high affinity AhR ligand (IC50 = 25 nM; Ki = 6.8 nM in a TCDD competitive binding study) and a known CYP1A1 inducer, neither property can fully account for its antitumor activity.
          FormWhite crystalline solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number872726-44-8
          Chemical formulaC₁₅H₁₂FNO₂S
          Structure formulaStructure formula
          Purity≥97% by HPLC
          SolubilityDMF (10 mg/ml) or DMSO (5 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesAiello, S., et al. 2008. J. Med. Chem. 51, 5135.
          Mortimer, C.G., et al. 2006. J. Med. Chem. 49, 179.