505764 | NMDA Antagonist XI, N1-dansyl-spermine - Calbiochem

505764
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₂₂H₃₇N₅O₂S•3HCl

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      5.05764.0001
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      Limited AvailabilityLimited Availability
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          Glass bottle 10 mg
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          Description
          OverviewAn N-sulfonyl-polyamine that acts as a potent and more specific antagonist of NMDA receptors expressed in Xenopus oocytes (IC50 = 310, 340 nM in NR1/NR2A and NR1/NR2B, respectively). The inhibition appears to be voltage-dependent and is non-competitive with respect to glutamate and glycine. Exhibits about 50-fold greater selectivity over NR1/NR2C and NR1/NR2D receptors (IC50 = 16 and 13 µM, respectively). Also shown to block c-AMP-dependent, calmodulin-activated phosphodiesterase (IC50 = 58 µM) and diminishes the induction of ornithine decarboxylase. At higher concentration (˜100 µM) it is shown to reduce spontaneous epileptiform activity in mouse cortical slices.
          Catalogue Number505764
          Brand Family Calbiochem®
          SynonymsNMDA channel blocker, N1-dansyl-spermine, N1-DnsSpm
          References
          ReferencesKirby, B.P., et al. 2005, Eur. J. Pharmacol. 524, 53.
          Li, J., et al. 2005, Brain Res. 1055, 180.
          Kirby, B. et al. 2004, Brain Res. 1011, 69.
          Seiler, N., et al. 1998, J. Biochem. Cell Biol. 30, 393.
          Chao, J., et al. 1997, Mol. Pharm. 51, 861.
          Product Information
          FormYellowish-white powder
          Hill Formula C₂₂H₃₇N₅O₂S•3HCl
          Chemical formulaC₂₂H₃₇N₅O₂S•3HCl
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetNMDA
          Primary Target IC<sub>50</sub>0.31 µ
          Purity≥97% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          References

          Reference overview
          Kirby, B.P., et al. 2005, Eur. J. Pharmacol. 524, 53.
          Li, J., et al. 2005, Brain Res. 1055, 180.
          Kirby, B. et al. 2004, Brain Res. 1011, 69.
          Seiler, N., et al. 1998, J. Biochem. Cell Biol. 30, 393.
          Chao, J., et al. 1997, Mol. Pharm. 51, 861.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision18-October-2013 JSW
          SynonymsNMDA channel blocker, N1-dansyl-spermine, N1-DnsSpm
          DescriptionAn N-sulfonyl-polyamine that acts as a potent and more specific antagonist of NMDA receptors expressed in Xenopus oocytes (IC50 = 310, 340 nM in NR1/NR2A and NR1/NR2B, respectively). The inhibition appears to be voltage-dependent and is non-competitive with respect to glutamate and glycine. Exhibits about 50-fold greater selectivity over NR1/NR2C and NR1/NR2D receptors (IC50 = 16 and 13 µM, respectively). Also shown to block c-AMP-dependent, calmodulin-activated phosphodiesterase (IC50 = 58 µM) and diminishes the induction of ornithine decarboxylase. At higher concentration (˜100 µM) it is shown to reduce spontaneous epileptiform activity in mouse cortical slices.
          FormYellowish-white powder
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₂₂H₃₇N₅O₂S•3HCl
          Structure formulaStructure formula
          Purity≥97% by HPLC
          SolubilityDMSO (100 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesKirby, B.P., et al. 2005, Eur. J. Pharmacol. 524, 53.
          Li, J., et al. 2005, Brain Res. 1055, 180.
          Kirby, B. et al. 2004, Brain Res. 1011, 69.
          Seiler, N., et al. 1998, J. Biochem. Cell Biol. 30, 393.
          Chao, J., et al. 1997, Mol. Pharm. 51, 861.