483125 | NG-Nitro-L-arginine Methyl Ester, Hydrochloride - CAS 51298-62-5 - Calbiochem

483125
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₇H₁₅N₅O₄ . HCl 51298-62-5

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      483125-100MG
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          Glass bottle 100 mg
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          Description
          OverviewCell permeable. More soluble analog of arginine and a competitive, slowly reversible inhibitor of eNOS (IC50 = 500 nM). Causes a prolonged inhibition of acetylcholine-induced relaxation of rat aortic rings (IC50 = 400 nM).
          Catalogue Number483125
          Brand Family Calbiochem®
          SynonymsNω-NO₂-L-Arg-OMe, NG-NO₂-L-Arg-OMe, L-NAME, HCl
          References
          ReferencesBaylis, C., et al. 1995. J. Pharmacol. Exp. Ther. 274, 1135.
          Dawson, V.L., et al. 1991. Proc. Natl. Acad. Sci. USA 88, 6368.
          Kubes, P., et al. 1991. Proc. Natl. Acad. Sci. USA 88, 4651.
          Moncada, S., et al. 1991. Pharmacol. Rev. 43, 109.
          Moore, P.K., et al. 1990. Br. J. Pharmacol. 99, 408.
          Product Information
          CAS number51298-62-5
          ATP CompetitiveN
          FormWhite to off-white solid
          Hill FormulaC₇H₁₅N₅O₄ . HCl
          Chemical formulaC₇H₁₅N₅O₄ . HCl
          Hygroscopic Hygroscopic
          ReversibleY
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargeteNOS
          Primary Target IC<sub>50</sub>500 nM against eNOS
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Blue Ice Only
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          483125

          References

          Reference overview
          Baylis, C., et al. 1995. J. Pharmacol. Exp. Ther. 274, 1135.
          Dawson, V.L., et al. 1991. Proc. Natl. Acad. Sci. USA 88, 6368.
          Kubes, P., et al. 1991. Proc. Natl. Acad. Sci. USA 88, 4651.
          Moncada, S., et al. 1991. Pharmacol. Rev. 43, 109.
          Moore, P.K., et al. 1990. Br. J. Pharmacol. 99, 408.

          Brochure

          Title
          Nitric Oxide and Oxidative Stress Brochure
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision29-November-2010 RFH
          SynonymsNω-NO₂-L-Arg-OMe, NG-NO₂-L-Arg-OMe, L-NAME, HCl
          DescriptionMore soluble analog of arginine and a competitive, slowly reversible inhibitor of endothelial nitric oxide synthase (IC50 = 500 nM). Causes a prolonged inhibition of acetylcholine-induced relaxation of rat aortic rings (IC50 = 400 nM).
          FormWhite to off-white solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number51298-62-5
          Chemical formulaC₇H₁₅N₅O₄ . HCl
          Structure formulaStructure formula
          Purity≥98% by HPLC
          SolubilityH₂O (50 mg/ml)
          Storage -20°C
          Hygroscopic
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C.
          Toxicity Standard Handling
          ReferencesBaylis, C., et al. 1995. J. Pharmacol. Exp. Ther. 274, 1135.
          Dawson, V.L., et al. 1991. Proc. Natl. Acad. Sci. USA 88, 6368.
          Kubes, P., et al. 1991. Proc. Natl. Acad. Sci. USA 88, 4651.
          Moncada, S., et al. 1991. Pharmacol. Rev. 43, 109.
          Moore, P.K., et al. 1990. Br. J. Pharmacol. 99, 408.