480403 | NFAT Activation Inhibitor III - CAS 3519-82-2 - Calbiochem

480403
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₀H₁₂O₂ 3519-82-2

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      480403-5MG
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          Plastic ampoule 5 mg
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          Description
          OverviewA cell-permeable quinone compound that acts as a potent and selective inhibitor of Calcineurin-NFAT (Nuclear Factor of Activated T cells) signaling. Binds to calcineurin with high affinity (Kd = 800 nM), disrupts its interaction with NFAT and completely blocks its dephosphorylation, nuclear import of NFAT (~40 µM in C1.7W2 T cells), and induction of cytokine mRNAs. Unlike CsA (Cat. No. 239835) and FK506, INCA-6 does not affect calcineurin activity or its downstream signaling.
          Catalogue Number480403
          Brand Family Calbiochem®
          SynonymsInhibitor of NFAT-Calcineurin Association-6, INCA-6
          References
          ReferencesRoehrl, M.H.A., et al. 2004. Biochemistry 43, 16067.
          Roehrl, M.H.A., et al. 2004. Proc. Natl. Acad. Sci. USA 101, 7554.
          Product Information
          CAS number3519-82-2
          ATP CompetitiveN
          FormYellow solid
          Hill FormulaC₂₀H₁₂O₂
          Chemical formulaC₂₀H₁₂O₂
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetCalcineurin-NFAT
          Primary Target IC<sub>50</sub>Kd = 800 nM for calcineurin-NFAT
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
          Toxicity Carcinogenic / Teratogenic
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          480403

          References

          Reference overview
          Roehrl, M.H.A., et al. 2004. Biochemistry 43, 16067.
          Roehrl, M.H.A., et al. 2004. Proc. Natl. Acad. Sci. USA 101, 7554.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision04-October-2007 RFH
          SynonymsInhibitor of NFAT-Calcineurin Association-6, INCA-6
          DescriptionA cell-permeable, potent, and selective inhibitor of Calcineurin-NFAT (Nuclear Factor of Activated T cells) signaling. Binds to calcineurin with high affinity (Kd = 800 nM), disrupts its interaction with NFAT, and completely blocks calcineurin-dependent NFAT dephosphorylation, nuclear import (~40 µM in C1.7W2 T cells), and induction of NFAT-targeted cytokine mRNAs. Unlike CsA (Cat. No. 239835) and FK506, INCA-6 does not affect calcineurin activity or its downstream signaling.
          FormYellow solid
          CAS number3519-82-2
          Chemical formulaC₂₀H₁₂O₂
          Structure formulaStructure formula
          Purity≥95% by HPLC
          SolubilityDMSO (5 mg/ml) or Ethanol (5 mg/ml). Use only fresh DMSO.
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Carcinogenic / Teratogenic
          ReferencesRoehrl, M.H.A., et al. 2004. Biochemistry 43, 16067.
          Roehrl, M.H.A., et al. 2004. Proc. Natl. Acad. Sci. USA 101, 7554.