480420 | NF449 - CAS 389142-38-5 - Calbiochem

480420
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₄₁H₂₄N₆O₂₉S₈ · 8Na 389142-38-5

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      480420-10MG
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          Glass bottle 10 mg
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          Description
          OverviewA potent Gsα-subunit-selective G-protein antagonist. Suppresses the rate of GTPγS binding to Gsα-s-subunit (IC50 = 140 nM) but not to Giα-1-subunit. Inhibits stimulation of adenylate cyclase activity in S49 cyc- cells (which lack endogenous Gsα-subunit) by exogenously added Gsα-subunit. Also blocks the coupling of β-adrenergic receptors to Gs (EC50 = 7.9 µM).
          Catalogue Number480420
          Brand Family Calbiochem®
          Synonyms4,4ʹ,4ʹʹ,4ʹʹʹ-[Carbonyl-bis[imino-5,1,3-benzenetriyl bis-(carbonylimino)]]tetrakis-(benzene-1,3-disulfonic Acid, 8Na)
          References
          ReferencesHulsmann, M., et al. 2003. Eur. J. Pharmacol. 470, 1.
          Hohenegger, M., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 346.
          Product Information
          CAS number389142-38-5
          ATP CompetitiveN
          FormWhite solid
          Hill FormulaC₄₁H₂₄N₆O₂₉S₈ · 8Na
          Chemical formulaC₄₁H₂₄N₆O₂₉S₈ · 8Na
          Hygroscopic Hygroscopic
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          ApplicationNF449, CAS 627034-85-9, is a potent Gsα-subunit-selective G-protein antagonist. Suppresses GTPγS binding to Gsα-s-subunit (IC50 = 140 nM). A highly potent P2X1 receptor antagonist (IC50 = 280 pM).
          Biological Information
          Primary TargetGsα-subunit-selective G-protein antagonist
          Primary Target IC<sub>50</sub>140 nM suppressing the rate of GTPγS binding to Gsα-s-subunit
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          480420

          References

          Reference overview
          Hulsmann, M., et al. 2003. Eur. J. Pharmacol. 470, 1.
          Hohenegger, M., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 346.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision04-May-2011 RFH
          Synonyms4,4ʹ,4ʹʹ,4ʹʹʹ-[Carbonyl-bis[imino-5,1,3-benzenetriyl bis-(carbonylimino)]]tetrakis-(benzene-1,3-disulfonic Acid, 8Na)
          DescriptionA potent G-selective G-protein antagonist. Suppresses the rate of GTPγS binding to Gsα-s (IC50 = 140 nM) but not in Giα-1. Inhibits stimulation of adenylate cyclase activity in S49 cyc cells (which lack endogenous G) by exogenously added Gsα-s. Also blocks the coupling of β-adrenergic receptors to Gs (EC50 = 7.9 µM). Acts as a reversible competitive antagonist of the human P2X receptor, exhibiting much higher potency at human P2X(1) than at P2X(7) receptors (IC50 = 50 nM vs 40 µM respectively).
          FormWhite solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number389142-38-5
          Chemical formulaC₄₁H₂₄N₆O₂₉S₈ · 8Na
          Structure formulaStructure formula
          Purity≥95% by HPLC
          SolubilitydH₂O (100 mg/ml)
          Storage +2°C to +8°C
          Hygroscopic
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesHulsmann, M., et al. 2003. Eur. J. Pharmacol. 470, 1.
          Hohenegger, M., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 346.