480418 | NF279 - CAS 202983-32-2 - Calbiochem

480418
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₄₉H₃₀N₆O₂₃S₆ · 6Na 202983-32-2

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      480418-5MG
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          Plastic ampoule 5 mg
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          Description
          OverviewA suramin analog that acts as a highly selective, competitive, and reversible ATP-antagonist of P2X receptor (IC50/KB ~ 1 µM in smooth muscle). Effectively discriminates between P2Y and P2X receptors with no effect on α1A adrenoceptors, adenosine A1 and A2B receptors, histamine H1, muscarinic M3 and neuronal nicotinic acetylcholine receptors. Displays a selectivity profile of P2X1 >P2X2 >P2X3 >P2X4 (IC50 = 19 nM, 770 nM, 1.62 µM and >300 µM, respectively) in Xenopus oocytes pre-incubated with ATP. In rat and human tissues, exhibits a potency profile of rat P2X1 > human P2X1 > > rat P2X2 > rat P2X3 ~ human P2X7 > > human P2X4. Not degraded by ecto-nucleotidases.
          Catalogue Number480418
          Brand Family Calbiochem®
          Synonyms8,8ʹ-(Carbonylbis(imino-4,1-phenylenecarbonylimino-4,1-phenylenecarbonylimino))bis-1,3,5-naphthalenetrisulfonic Acid, Na
          References
          ReferencesKlapperstück, M., et al. 2000. Eur. J. Pharmacol. 387, 245.
          Rettinger, J., et al. 2000. Neuropharmacol. 39, 2044.
          Lambrecht, G., et al. 1999. Prog. Brain Res. 120,107.
          Damer, S., et al. 1998. Eur. J. Pharmacol. 350, R5.
          Product Information
          CAS number202983-32-2
          ATP CompetitiveY
          FormWhite solid
          Hill FormulaC₄₉H₃₀N₆O₂₃S₆ · 6Na
          Chemical formulaC₄₉H₃₀N₆O₂₃S₆ · 6Na
          ReversibleY
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetP2X receptor
          Primary Target IC<sub>50</sub>~ 1 µM as antagonist of P2X receptor in smooth muscle; 19 nM, 770 nM, 1.62 µM and <300 µM, against P2X1, P2X2, P2X3, P2X4, respectively, in Xenopus oocytes pre-incubated with ATP
          Purity≥99% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Protect from Moisture Protect from moisture
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          480418

          References

          Reference overview
          Klapperstück, M., et al. 2000. Eur. J. Pharmacol. 387, 245.
          Rettinger, J., et al. 2000. Neuropharmacol. 39, 2044.
          Lambrecht, G., et al. 1999. Prog. Brain Res. 120,107.
          Damer, S., et al. 1998. Eur. J. Pharmacol. 350, R5.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision11-August-2008 RFH
          Synonyms8,8ʹ-(Carbonylbis(imino-4,1-phenylenecarbonylimino-4,1-phenylenecarbonylimino))bis-1,3,5-naphthalenetrisulfonic Acid, Na
          DescriptionA suramin analog that acts as a highly selective, competitive, and reversible ATP-antagonist of P2X receptor (IC50/KB ~1 µM in smooth muscle). Effectively discriminates between P2Y and P2X receptors with no discernible effects on α1A adrenoceptors, adenosine A1 and A2B receptors, histamine H1, muscarinic M3 and neuronal nicotinic acetylcholine receptors. Displays a selectivity profile of P2X1 >P2X2 >P2X3 >P2X4 (IC50 = 19 nM, 770 nM, 1.62 µM and >300 µM, respectively) in Xenopus oocytes pre-incubated with ATP. In rat and human tissues, exhibits a potency profile of rat P2X1 > human P2X1 » rat P2X2 > rat P2X3 ~human P2X7 » human P2X4. Not degraded by ecto-nucleotidases.
          FormWhite solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number202983-32-2
          Chemical formulaC₄₉H₃₀N₆O₂₃S₆ · 6Na
          Structure formulaStructure formula
          Purity≥99% by HPLC
          SolubilityDMSO (14 mg/ml) or H₂O (35 mg/ml)
          Storage +2°C to +8°C
          Protect from moisture
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
          Toxicity Standard Handling
          ReferencesKlapperstück, M., et al. 2000. Eur. J. Pharmacol. 387, 245.
          Rettinger, J., et al. 2000. Neuropharmacol. 39, 2044.
          Lambrecht, G., et al. 1999. Prog. Brain Res. 120,107.
          Damer, S., et al. 1998. Eur. J. Pharmacol. 350, R5.