480458 NF-κB Activation Inhibitor X, Methysticin - CAS 495-85-2 - Calbiochem

480458
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      Overview

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      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      480458-5MG
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          Glass bottle 5 mg
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          Description
          OverviewMethysticin has been identified from kava to have potent NF-κB inhibitory activity and minimum toxicity. It is shown to inhibit NF-κB (IC50 = 0.19 µg/ml) 100 times more potently than traditional kava in A549 cells in an in vitro luciferase-based assay. It is also reported to suppress the elevation of IKKα, p65, and COX-2 and the degradation of IκBα in A549 cultures stimulated with TNF-alpha; through Western Blot analysis.
          Catalogue Number480458
          Brand Family Calbiochem®
          Synonyms(6R)-6-[(1E)-2-(1,3-Benzodioxol-5-yl)ethenyl]-5,6- dihydro-4- methoxy-2H-pyran-2-one
          References
          ReferencesShaik, A.A., et al. 2009. Bioorg Med Chem Lett. 19, 5732.
          Product Information
          CAS number495-85-2
          FormWhite solid
          Hill FormulaC₁₅H₁₄O₅
          Chemical formulaC₁₅H₁₄O₅
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Purity≥99% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped with Blue Ice or with Dry Ice
          Toxicity Standard Handling
          Storage -20°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          References

          Reference overview
          Shaik, A.A., et al. 2009. Bioorg Med Chem Lett. 19, 5732.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision26-April-2013 JSW
          Synonyms(6R)-6-[(1E)-2-(1,3-Benzodioxol-5-yl)ethenyl]-5,6- dihydro-4- methoxy-2H-pyran-2-one
          DescriptionMethysticin has been identified from kava to have potent NF-κB inhibitory activity and minimum toxicity. It is shown to inhibit NF-κB (IC50 = 0.19 µg/ml) 100 times more potently than traditional kava in A549 cells in an in vitro luciferase-based assay. It is also reported to suppress the elevation of IKKα, p65, and COX-2 and the degradation of IκBα in A549 cultures stimulated with TNF-alpha; through Western Blot analysis.
          FormWhite solid
          CAS number495-85-2
          Chemical formulaC₁₅H₁₄O₅
          Structure formulaStructure formula
          Purity≥99% by HPLC
          SolubilityDMSO (50 mg/ml)
          Storage -20°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesShaik, A.A., et al. 2009. Bioorg Med Chem Lett. 19, 5732.