481411 | NF-κB Activation Inhibitor III - CAS 380623-76-7 - Calbiochem

481411
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₀H₅ClN₄O₅S 380623-76-7

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      481411-5MG
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          Glass bottle 5 mg
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          Description
          OverviewA cell-permeable thiazoloamide compound that inhibits TNF-α-stimulated NF-κB activation and subsequent upregulation of MMP-9 in HT1080 cells (complete inhibition at 10 µM). The inhibition of MMP-9 upregulation correlates with a concomitant inhibition of TNF-α-dependent cell invasion. Does not affect TNF-α-induced AP-1 activity. The cellular target appears to be downstream of p38 activation.
          Catalogue Number481411
          Brand Family Calbiochem®
          Synonyms3-Chloro-4-nitro-N-(5-nitro-2-thiazolyl)-benzamide, SM-7368
          References
          ReferencesLee, H.Y., et al. 2005. Biochem. Biophys. Res. Commun. 336, 716.
          Product Information
          CAS number380623-76-7
          ATP CompetitiveN
          FormLight yellow amorphous solid
          Hill FormulaC₁₀H₅ClN₄O₅S
          Chemical formulaC₁₀H₅ClN₄O₅S
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetTNF-α-stimulated NF-κB activation and upregulation of MMP-9
          Primary Target IC<sub>50</sub>Effective concentration: 10 µM for complete inhibition of TNF-α-stimulated NF-κB activation and subsequent upregulation of MMP-9 in HT1080 cells
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Irritant
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          481411

          References

          Reference overview
          Lee, H.Y., et al. 2005. Biochem. Biophys. Res. Commun. 336, 716.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision11-August-2008 RFH
          Synonyms3-Chloro-4-nitro-N-(5-nitro-2-thiazolyl)-benzamide, SM-7368
          DescriptionA cell-permeable inhibitor of TNF-α-stimulated NF-κB activation and subsequent upregulation of MMP-9 in HT1080 cells (complete inhibition at 10 µM). The inhibition of MMP-9 upregulation correlates with a concomitant inhibition of TNF-α-dependent cell invasion. Does not affect TNF-α-induced AP-1 activity. The cellular target appears to be downstream of p38 activation.
          FormLight yellow amorphous solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number380623-76-7
          Chemical formulaC₁₀H₅ClN₄O₅S
          Structure formulaStructure formula
          Purity≥98% by HPLC
          SolubilityDMSO (10 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Irritant
          ReferencesLee, H.Y., et al. 2005. Biochem. Biophys. Res. Commun. 336, 716.