399275 | Nω-Hydroxy-nor-L-arginine, Diacetate Salt - CAS 189302-40-7 - Calbiochem

399275
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₅H₁₂N₄O₃ · 2CH₃CO₂H 189302-40-7

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      399275-1MG
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          Plastic ampoule 1 mg
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          399275-5MG
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              Description
              OverviewA potent, selective, competitive, and high affinity inhibitor of arginase. Shown to inhibit arginase from rat liver (IC50 = 2 µM) and mouse macrophages (IC50 = 50 µM). Shown to specifically interact with the manganese-cluster of the enzyme active site. Does not function as a substrate or as an inhibitor for NOS. Hence, nor-NOHA may be a useful tool to study the interplays between arginase and NOS.
              Catalogue Number399275
              Brand Family Calbiochem®
              Synonymsnor-NOHA, 2CH₃CO₂H, L-2-Amino-(4-(2ʹ-hydroxyguanidino)butyric Acid, 2CH₃CO₂H
              References
              ReferencesGobert, A.P., et al. 2000. Infect. Immun. 68, 4653.
              Meurs, H., et al. 2000. Br. J. Pharmacol. 130, 1793.
              Moali, C., et al. 2000. Biochemistry 39, 8208.
              Tenu, J.P. et al. 1999. Nitric Oxide 3, 427.
              Moali, C., et al. 1998. Biochemistry 37, 10453.
              Custot, J., et al. 1997. J. Am. Chem. Soc. 119, 4086.
              Product Information
              CAS number189302-40-7
              FormOff-white solid
              Hill FormulaC₅H₁₂N₄O₃ · 2CH₃CO₂H
              Chemical formulaC₅H₁₂N₄O₃ · 2CH₃CO₂H
              Hygroscopic Hygroscopic
              Structure formula ImageStructure formula Image
              Applications
              ApplicationNω-Hydroxy-nor-L-arginine, Diacetate Salt, CAS 189302-40-7, is a potent, selective, competitive, and high affinity inhibitor of arginase (IC50 = 2 µM for rat liver and 50 µM for mouse macrophages).
              Biological Information
              Primary Targetarginase from rat liver
              Primary Target IC<sub>50</sub>2 µM
              Secondary targetmouse macrophages (IC₅₀ = 50 µM)
              Purity≥97% by TLC
              Physicochemical Information
              Dimensions
              Materials Information
              Toxicological Information
              Safety Information according to GHS
              Safety Information
              Product Usage Statements
              Storage and Shipping Information
              Ship Code Ambient Temperature Only
              Toxicity Standard Handling
              Storage -20°C
              Hygroscopic Hygroscopic
              Do not freeze Ok to freeze
              Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
              Packaging Information
              Packaged under inert gas Packaged under inert gas
              Transport Information
              Supplemental Information
              Specifications

              Documentation

              SDS

              Title

              Safety Data Sheet (SDS) 

              Certificates of Analysis

              TitleLot Number
              399275

              References

              Reference overview
              Gobert, A.P., et al. 2000. Infect. Immun. 68, 4653.
              Meurs, H., et al. 2000. Br. J. Pharmacol. 130, 1793.
              Moali, C., et al. 2000. Biochemistry 39, 8208.
              Tenu, J.P. et al. 1999. Nitric Oxide 3, 427.
              Moali, C., et al. 1998. Biochemistry 37, 10453.
              Custot, J., et al. 1997. J. Am. Chem. Soc. 119, 4086.

              Brochure

              Title
              Nitric Oxide and Oxidative Stress Brochure
              Data Sheet

              Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

              Revision16-October-2007 JSW
              Synonymsnor-NOHA, 2CH₃CO₂H, L-2-Amino-(4-(2ʹ-hydroxyguanidino)butyric Acid, 2CH₃CO₂H
              DescriptionA potent, selective, competitive, and high affinity inhibitor of arginase. Shown to inhibit arginase from rat liver (IC50 = 2 µM) and mouse macrophages (IC50 = 50 µM). Specifically interacts with the manganese-cluster of the enzyme active site. Does not act as a substrate or as an inhibitor of NOS. Hence, it may serve as a useful tool to study the interplays between arginase and NOS.
              FormOff-white solid
              Intert gas (Yes/No) Packaged under inert gas
              CAS number189302-40-7
              Chemical formulaC₅H₁₂N₄O₃ · 2CH₃CO₂H
              Structure formulaStructure formula
              Purity≥97% by TLC
              SolubilityH₂O (50 mg/ml)
              Storage -20°C
              Hygroscopic
              Do Not Freeze Ok to freeze
              Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
              Toxicity Standard Handling
              ReferencesGobert, A.P., et al. 2000. Infect. Immun. 68, 4653.
              Meurs, H., et al. 2000. Br. J. Pharmacol. 130, 1793.
              Moali, C., et al. 2000. Biochemistry 39, 8208.
              Tenu, J.P. et al. 1999. Nitric Oxide 3, 427.
              Moali, C., et al. 1998. Biochemistry 37, 10453.
              Custot, J., et al. 1997. J. Am. Chem. Soc. 119, 4086.