509884 | Myristoylated-FEEERA, mP6 - Calbiochem

509884
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₄₇H₇₅N₉O₁₄

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      5.09884.0001
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          Glass bottle 10 mg
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          Description
          OverviewA cell-permeable myristoylated hexapeptide derived from EXE-motif-containing integrin β3 subunit that selectively inhibits integrin outside-in signaling without affecting inside-out signaling . Shown to specifically block the interaction of Gα3 and integrin β3 subunit resulting in the inhibition of Gα13-dependent early phase outside-in signaling. Selectively inhibits thrombosis without affecting haemostasis.

          Please note that the molecular weight for this compound is batch-specific due to variable water content.
          Catalogue Number509884
          Brand Family Calbiochem®
          SynonymsIntegrin Signaling Inhibitor I, mP6
          References
          ReferencesShen, B., et al. 2013. Nature 503, 131.
          Product Information
          FormWhite powder
          Hill FormulaC₄₇H₇₅N₉O₁₄
          Chemical formulaC₄₇H₇₅N₉O₁₄
          Hygroscopic Hygroscopic
          ReversibleY
          Applications
          Biological Information
          Primary Targetplatelet integrin →IIb→3
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableY
          Peptide SequenceFEEERA
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
          Toxicity Standard Handling
          Storage ≤ -70°C
          Protect from Light Protect from light
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-207deg;C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          References

          Reference overview
          Shen, B., et al. 2013. Nature 503, 131.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision09-May-2014 JSW
          SynonymsIntegrin Signaling Inhibitor I, mP6
          DescriptionA cell-permeable myristoylated hexapeptide derived from EXE-motif-containing integrin β3 subunit that selectively inhibits integrin outside-in signaling without affecting inside-out signaling . Shown to specifically block the interaction of Gα3 and integrin β3 subunit resulting in the inhibition of Gα13-dependent early phase outside-in signaling. Selectively inhibits thrombosis without affecting haemostasis.
          FormWhite powder
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₄₇H₇₅N₉O₁₄
          Peptide SequenceFEEERA
          Purity≥98% by HPLC
          SolubilityDMSO (100 mg/ml)
          Storage ≤ -70°C
          Hygroscopic
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-207deg;C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesShen, B., et al. 2013. Nature 503, 131.