476300 | Myriocin, Mycelia sterilia - CAS 35891-70-4 - Calbiochem

476300
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₁H₃₉NO₆ 35891-70-4

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      476300-5MG
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          Plastic ampoule 5 mg
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          Description
          OverviewA potent immunosuppressant. Displays 10- to 100-fold more potent immunosuppressant activity than cyclosporin A. Potently inhibits serine palmitoyltransferase (SPT; Ki = 280 pM) thereby blocking the synthesis of ceramide. Disrupts substratum adhesion of melanoma cells. Inhibits cell proliferation and induces apoptosis in IL-2 dependent murine cytotoxic T lymphocyte cell line CTLL-2.
          Catalogue Number476300
          Brand Family Calbiochem®
          SynonymsISP-1, Thermozymocidin, [2S,3R,4R]-(E)-2-Amino-3,4-dihydroxy-2-[hydroxymethyl]-14-oxo-6-eicosenoic Acid
          References
          ReferencesHanada, K., et al. 2000. Biochem. Pharmacol. 59, 1211.
          Chen, J.K., et al. 1999. Chem. Biol. 6, 221.
          Hidari, K.I.P.J., et al. 1996. J. Biol. Chem. 271, 14636.
          Nakamura, S., et al. 1996. J. Biol. Chem. 271, 1255.
          Mikaye, Y., et al. 1995. Biochem. Biophys. Res. Commun. 211, 396.
          Fujita, T., et al. 1994. J. Antibiot. 47, 208.
          Product Information
          CAS number35891-70-4
          ATP CompetitiveN
          FormWhite solid
          Hill FormulaC₂₁H₃₉NO₆
          Chemical formulaC₂₁H₃₉NO₆
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetSerine palmitoyltransferase
          Primary Target K<sub>i</sub>280 pM against serine palmitoyltransferase
          Purity≥95% by TLC
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSJX3890000
          Safety Information
          R PhraseR: 22

          Harmful if swallowed.
          S PhraseS: 36

          Wear suitable protective clothing.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Harmful
          Storage -20°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          476300

          References

          Reference overview
          Hanada, K., et al. 2000. Biochem. Pharmacol. 59, 1211.
          Chen, J.K., et al. 1999. Chem. Biol. 6, 221.
          Hidari, K.I.P.J., et al. 1996. J. Biol. Chem. 271, 14636.
          Nakamura, S., et al. 1996. J. Biol. Chem. 271, 1255.
          Mikaye, Y., et al. 1995. Biochem. Biophys. Res. Commun. 211, 396.
          Fujita, T., et al. 1994. J. Antibiot. 47, 208.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision11-August-2008 RFH
          SynonymsISP-1, Thermozymocidin, [2S,3R,4R]-(E)-2-Amino-3,4-dihydroxy-2-[hydroxymethyl]-14-oxo-6-eicosenoic Acid
          DescriptionA potent immunosuppressant. Displays 10- to 100-fold more potent immunosuppressant activity than cyclosporin A. Potently inhibits serine palmitoyltransferase (SPT; Ki = 280 pM) thereby blocking the synthesis of ceramide. Disrupts substratum adhesion of melanoma cells. Inhibits cell proliferation and induces apoptosis in IL-2 dependent murine cytotoxic T lymphocyte cell line CTLL-2.
          FormWhite solid
          CAS number35891-70-4
          RTECSJX3890000
          Chemical formulaC₂₁H₃₉NO₆
          Structure formulaStructure formula
          Purity≥95% by TLC
          SolubilityDMSO (25 mg/ml)
          Storage -20°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Harmful
          ReferencesHanada, K., et al. 2000. Biochem. Pharmacol. 59, 1211.
          Chen, J.K., et al. 1999. Chem. Biol. 6, 221.
          Hidari, K.I.P.J., et al. 1996. J. Biol. Chem. 271, 14636.
          Nakamura, S., et al. 1996. J. Biol. Chem. 271, 1255.
          Mikaye, Y., et al. 1995. Biochem. Biophys. Res. Commun. 211, 396.
          Fujita, T., et al. 1994. J. Antibiot. 47, 208.