475870 | MnTBAP - Calbiochem

475870
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₄₈H₂₈ClMnN₄O₈ 55266-18-7

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      475870-25MG
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          Plastic ampoule 25 mg
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          Description
          OverviewCell-permeable superoxide dismutase (SOD) mimetic and peroxynitrite scavenger. Protects endothelial cells in a dose-dependent manner (EC50 ~40 µM) against paraquat (2 mM). Inhibits the oxidation of Dihydrorhodamine 123 (Cat. No. 309825) by peroxynitrite, but does not scavenge nitric oxide (NO).
          Catalogue Number475870
          Brand Family Calbiochem®
          SynonymsMn(III)tetrakis(4-benzoic acid)porphyrin Chloride
          References
          ReferencesAladag, M. A., et al. 2003. Acta Neurochir. 145, 673.
          Szabo, C., et al. 1996. FEBS Lett. 381, 82.
          Day, B.J., et al. 1995. J. Pharmacol. Exp. Ther. 275, 1227.
          Faulkner, K.M., et al. 1994. J. Biol. Chem. 269, 23471.
          Product Information
          CAS number55266-18-7
          ATP CompetitiveN
          FormBrown solid
          Hill FormulaC₄₈H₂₈ClMnN₄O₈
          Chemical formulaC₄₈H₂₈ClMnN₄O₈
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          ApplicationMnTBAP, CAS 55266-18-7, is a cell-permeable superoxide dismutase (SOD) mimetic and peroxynitrite scavenger.
          Biological Information
          Primary TargetSuperoxide dismutase (SOD) mimetic
          Primary Target IC<sub>50</sub>EC50 ~40 µM in protecting endothelial cells against paraquat (2 mM)
          Purity≥95% by TLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Protect from Moisture Protect from moisture
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          475870

          References

          Reference overview
          Aladag, M. A., et al. 2003. Acta Neurochir. 145, 673.
          Szabo, C., et al. 1996. FEBS Lett. 381, 82.
          Day, B.J., et al. 1995. J. Pharmacol. Exp. Ther. 275, 1227.
          Faulkner, K.M., et al. 1994. J. Biol. Chem. 269, 23471.

          Brochure

          Title
          Nitric Oxide and Oxidative Stress Brochure

          Citations

          Title
        • Yumin Zhang, et al. (2004) Peroxynitrite-Induced Neuronal Apoptosis is Mediated by Intracellular Zinc Release and 12-Lipoxygenase Activation. Journal of Neuroscience 24, 10616-10627.
        • Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision11-August-2008 RFH
          SynonymsMn(III)tetrakis(4-benzoic acid)porphyrin Chloride
          DescriptionCell-permeable superoxide dismutase (SOD) mimetic and peroxynitrite scavenger. Protects endothelial cells in a dose-dependent manner (EC50 ~40 µM) against paraquat (2 mM). Inhibits the oxidation of dihydrorhodamine-123 by peroxynitrite, but does not scavenge nitric oxide (NO).
          FormBrown solid
          CAS number55266-18-7
          Chemical formulaC₄₈H₂₈ClMnN₄O₈
          Structure formulaStructure formula
          Purity≥95% by TLC
          SolubilityAqueous alkaline solution
          Storage -20°C
          Protect from moisture
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Standard Handling
          ReferencesAladag, M. A., et al. 2003. Acta Neurochir. 145, 673.
          Szabo, C., et al. 1996. FEBS Lett. 381, 82.
          Day, B.J., et al. 1995. J. Pharmacol. Exp. Ther. 275, 1227.
          Faulkner, K.M., et al. 1994. J. Biol. Chem. 269, 23471.
          Citation
        • Yumin Zhang, et al. (2004) Peroxynitrite-Induced Neuronal Apoptosis is Mediated by Intracellular Zinc Release and 12-Lipoxygenase Activation. Journal of Neuroscience 24, 10616-10627.