533998 Mitotic Tracker Probe, CDy6 - Calbiochem

533998
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₃₄H₄₇BF₂N₄O₂

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      5.33998.0001
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          Glass bottle 5 mg
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          Description
          OverviewA cell-permeable, photostable, bodipy-derived fluorescent probe that can be used for real-time imaging of lysosomal dynamics in proliferating cells undergoing mitosis. Undergoes rapid re-localization from cytoplasm to nucleus during cell division, but does not interfere with cell cycle. Displays a sharp increase in intensity during mitosis and its fluorescence displays high sensitivity to acidic environment (pH 2-4). Can also be used for time-dependent whole-body in vivo imaging of tumor xenografts (CDy6 stained HeLa cells, s.c.) in BALB/c nude mice up to 21 days. Exhibits greater brightness, higher photostability, and significantly reduced toxicity when compared to LysoTracker Red, LysoTracker Green, LysoSensor Green and HOE33342. Abs max: 570 nm; Em max: 585 with a quantum yield of 0.89.

          Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.
          Catalogue Number533998
          Brand Family Calbiochem®
          Synonyms(E)-7-(3,5-di-tert-Butyl-2-methoxystyryl)-3-(3-(2-(dimethylamino)ethylamino)-3-oxopropyl)-5,5-difluoro-9-methyl-5H-dipyrrolo[1,2-c:1ʹ,2ʹ-f][1,3,2]diazaborinin-4-ium-5-uide, Lysosomal Tracker Probe, CDy6
          References
          ReferencesJeong, Y.M., et al. 2015. Chem. Biol. 22, 299.
          Product Information
          FormDark purple powder
          Hill FormulaC₃₄H₄₇BF₂N₄O₂
          Chemical formulaC₃₄H₄₇BF₂N₄O₂
          ReversibleY
          Applications
          Biological Information
          Primary Targetcytoplasm
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableY
          Emission max.
          Excitation max.
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C). Store in a dark vial, protected from light.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Mitotic Tracker Probe, CDy6 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          References

          Reference overview
          Jeong, Y.M., et al. 2015. Chem. Biol. 22, 299.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision09-December-2016 JSW
          Synonyms(E)-7-(3,5-di-tert-Butyl-2-methoxystyryl)-3-(3-(2-(dimethylamino)ethylamino)-3-oxopropyl)-5,5-difluoro-9-methyl-5H-dipyrrolo[1,2-c:1ʹ,2ʹ-f][1,3,2]diazaborinin-4-ium-5-uide, Lysosomal Tracker Probe, CDy6
          DescriptionA cell-permeable, photostable, bodipy-derived fluorescent probe that can be used for real-time imaging of lysosomal dynamics in proliferating cells undergoing mitosis. Undergoes rapid re-localization from cytoplasm to nucleus during cell division, but does not interfere with cell cycle. Displays a sharp increase in intensity during mitosis and its fluorescence displays high sensitivity to acidic environment (pH 2-4). Can also be used for time-dependent whole-body in vivo imaging of tumor xenografts (CDy6 stained HeLa cells, s.c.) in BALB/c nude mice up to 21 days. Exhibits greater brightness, higher photostability, and significantly reduced toxicity when compared to LysoTracker Red, LysoTracker Green, LysoSensor Green and HOE33342. Abs max: 570 nm; Em max: 585 with a quantum yield of 0.89.
          FormDark purple powder
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₃₄H₄₇BF₂N₄O₂
          Purity≥98% by HPLC
          SolubilityDMSO (10 mg/ml). Use only fresh, anhydrous DMSO for reconstitution.
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C). Store in a dark vial, protected from light.
          Toxicity Standard Handling
          ReferencesJeong, Y.M., et al. 2015. Chem. Biol. 22, 299.