475841 | Miltefosine - CAS 58066-85-6 - Calbiochem

475841
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₁H₄₆NO₄P 58066-85-6

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      475841-50MG
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          Plastic ampoule 50 mg
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          Description
          OverviewAn ether lipid analog that acts as an inhibitor of CTP:phosphocholine cytidyltransferase and displays remarkable antiproliferative effect both in vitro and in vivo. Also induces apoptosis mediated by cell-permeable ceramides.
          Catalogue Number475841
          Brand Family Calbiochem®
          SynonymsHePC, 1-Hexadecylphosphorylcholine
          References
          ReferencesWieder, T., et al. 1998. J. Biol. Chem. 273, 11025.
          Wieder, T., et al. 1993. Biochem. J. 291, 561.
          Geilen, C.C., et al. 1992. J. Biol. Chem. 267, 6719.
          Geilen, C.C., et al. 1991. Eur. J. Cancer 27, 1650.
          Product Information
          CAS number58066-85-6
          ATP CompetitiveN
          FormCrystalline solid
          Hill FormulaC₂₁H₄₆NO₄P
          Chemical formulaC₂₁H₄₆NO₄P
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetCTP:phosphocholine cytidyltransferase
          Purity≥98% by TLC
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSKH2890000
          Safety Information
          R PhraseR: 20/21/22-36/37/38

          Harmful by inhalation, in contact with skin and if swallowed.
          Irritating to eyes, respiratory system and skin.
          S PhraseS: 22-26-36

          Do not breathe dust.
          In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
          Wear suitable protective clothing.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Harmful
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution in ethanol or DMSO, aliquot and freeze (-20°C). Stock solutions in ethanol or DMSO are stable for up to 3 months at -20°C. Stock solutions in PBS are stable for up to 24 h at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          475841

          References

          Reference overview
          Wieder, T., et al. 1998. J. Biol. Chem. 273, 11025.
          Wieder, T., et al. 1993. Biochem. J. 291, 561.
          Geilen, C.C., et al. 1992. J. Biol. Chem. 267, 6719.
          Geilen, C.C., et al. 1991. Eur. J. Cancer 27, 1650.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision08-August-2008 RFH
          SynonymsHePC, 1-Hexadecylphosphorylcholine
          DescriptionAn ether lipid analog that acts as an inhibitor of CTP:phosphocholine cytidyltransferase. Reported to exhibit anti-proliferative and anti-metastatic effects in vitro and in vivo. Also reported to induce apoptosis mediated by cell-permeable ceramides. Shown to have anti-protozoal activity against Leishmania species.
          FormCrystalline solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number58066-85-6
          RTECSKH2890000
          Chemical formulaC₂₁H₄₆NO₄P
          Structure formulaStructure formula
          Purity≥98% by TLC
          SolubilityDMSO (800 μg/ml), Ethanol (1 mg/ml), or PBS, pH 7.2 (2.5 mg/ml)
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution in ethanol or DMSO, aliquot and freeze (-20°C). Stock solutions in ethanol or DMSO are stable for up to 3 months at -20°C. Stock solutions in PBS are stable for up to 24 h at -20°C.
          Toxicity Harmful
          ReferencesWieder, T., et al. 1998. J. Biol. Chem. 273, 11025.
          Wieder, T., et al. 1993. Biochem. J. 291, 561.
          Geilen, C.C., et al. 1992. J. Biol. Chem. 267, 6719.
          Geilen, C.C., et al. 1991. Eur. J. Cancer 27, 1650.