454126 | Methotrexate - CAS 59-05-2 - Calbiochem

454126
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₀H₂₂N₈O₅ • 3H₂O 59-05-2

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      454126-100MG
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          Glass bottle 100 mg
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          Description
          OverviewInhibits thymidylate synthetase, is a nonselective de novo purine synthesis inhibitor, and has a significant toxicity profile including hepatotoxicity, pneumonitis, and bone marrow suppression. Potent folic acid antagonist. Induces apoptosis in HL-60 human leukemia cells. Also useful as an antitumor agent.
          Catalogue Number454126
          Brand Family Calbiochem®
          References
          ReferencesKaufman, S.H., et al. 1993. Cancer Res. 53, 3976.
          Takasuga, A., et al. 1992. J. Biochem. 112, 652.
          Hirata, S., et al. 1989. Arthritis Rheum. 32, 1065.
          Jolivet, J., et al. 1983. New Engl. J. Med. 309, 1094.
          Product Information
          CAS number59-05-2
          FormYellow solid
          Hill FormulaC₂₀H₂₂N₈O₅ • 3H₂O
          Chemical formulaC₂₀H₂₂N₈O₅ • 3H₂O
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Purity≥98% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          R PhraseR: 23/24/25-36/37/38-45-46

          Toxic by inhalation, in contact with skin and if swallowed.
          Irritating to eyes, respiratory system and skin.
          May cause cancer.
          May cause heritable genetic damage.
          S PhraseS: 22-24/25-36/37/39

          Do not breathe dust.
          Avoid contact with skin and eyes.
          Wear suitable protective clothing, gloves and eye/face protection.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Toxic
          Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          454126

          References

          Reference overview
          Kaufman, S.H., et al. 1993. Cancer Res. 53, 3976.
          Takasuga, A., et al. 1992. J. Biochem. 112, 652.
          Hirata, S., et al. 1989. Arthritis Rheum. 32, 1065.
          Jolivet, J., et al. 1983. New Engl. J. Med. 309, 1094.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision13-October-2010 RFH
          DescriptionInhibits thymidylate synthetase, is a nonselective de novo purine synthesis inhibitor and has a significant toxicity profile including hepatotoxicity, pneumonitis and bone marrow suppression. Potent folic acid antagonist. Induces apoptosis in HL-60 human leukemia cells. Also useful as an anti-tumor agent.
          FormYellow solid
          CAS number59-05-2
          Chemical formulaC₂₀H₂₂N₈O₅ • 3H₂O
          Structure formulaStructure formula
          Purity≥98% by HPLC
          SolubilityDMSO (100 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Toxic
          Merck USA index14, 5985
          ReferencesKaufman, S.H., et al. 1993. Cancer Res. 53, 3976.
          Takasuga, A., et al. 1992. J. Biochem. 112, 652.
          Hirata, S., et al. 1989. Arthritis Rheum. 32, 1065.
          Jolivet, J., et al. 1983. New Engl. J. Med. 309, 1094.