317240 | Metformin - CAS 1115-70-4 - Calbiochem

317240
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₄H₁₁N₅ • HCl 1115-70-4

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      317240-5GM
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          Glass bottle 5 gm
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          Description
          OverviewAn antihyperglycemic agent that lowers blood glucose levels without stimulating insulin secretion, promoting weight gain or causing hypoglycemia. Reported to stimulate AMP-activated protein kinase (AMPK) leading to the reduction in acetyl-CoA carboxylase (ACC) activity and induction of fatty acid oxidation.
          Catalogue Number317240
          Brand Family Calbiochem®
          Synonyms1,1-Dimethylbiguanide, Hydrochloride, AMPK Signaling Activator VII
          References
          ReferencesCleasby, M.E., et al. 2004. Diabetes 53, 3258.
          Klein, J., et al. 2004. J. Endocrinol. 183, 299.
          Zhou, G., et al. 2001. J. Clin. Invest. 108, 1167.
          Lin, H.Z., et al. 2000. Nat. Med. 6, 998.
          Product Information
          CAS number1115-70-4
          ATP CompetitiveN
          FormWhite solid
          Hill FormulaC₄H₁₁N₅ • HCl
          Chemical formulaC₄H₁₁N₅ • HCl
          Hygroscopic Hygroscopic
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          ApplicationMetformin, CAS 1115-70-4, lowers blood glucose levels without stimulating insulin secretion. Stimulates AMPK leading to the reduction in acetyl-CoA carboxylase (ACC) activity.
          Biological Information
          Primary TargetAMP-activated protein kinase (AMPK)
          Purity≥97% by Titration
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSDU1800000
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Irritant
          Storage +15°C to +30°C
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          317240

          References

          Reference overview
          Cleasby, M.E., et al. 2004. Diabetes 53, 3258.
          Klein, J., et al. 2004. J. Endocrinol. 183, 299.
          Zhou, G., et al. 2001. J. Clin. Invest. 108, 1167.
          Lin, H.Z., et al. 2000. Nat. Med. 6, 998.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision01-May-2008 RFH
          Synonyms1,1-Dimethylbiguanide, Hydrochloride, AMPK Signaling Activator VII
          DescriptionAn anti-hyperglycemic agent that acts by lowering the hepatic output of glucose. Does not stimulate insulin secretion, promote weight gain, or cause hypoglycemia. Reported to stimulate AMP-activated protein kinase (AMPK), leading to the reduction in acetyl-CoA carboxylase (ACC) activity and induction of fatty acid oxidation.
          FormWhite solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number1115-70-4
          RTECSDU1800000
          Chemical formulaC₄H₁₁N₅ • HCl
          Structure formulaStructure formula
          Purity≥97% by Titration
          SolubilityH₂O (50 mg/ml)
          Storage +15°C to +30°C
          Hygroscopic
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Irritant
          Merck USA index14, 5938
          ReferencesCleasby, M.E., et al. 2004. Diabetes 53, 3258.
          Klein, J., et al. 2004. J. Endocrinol. 183, 299.
          Zhou, G., et al. 2001. J. Clin. Invest. 108, 1167.
          Lin, H.Z., et al. 2000. Nat. Med. 6, 998.