445888 | Metastin (45-54) - Calbiochem

445888
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₆₃H₈₃N₁₇O₁₄

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      445888-1MG
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          Plastic ampoule 1 mg
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          Description
          OverviewA decapeptide with C-terminally amidated LRF-motif that acts as a potent and selective agonist of AXOR12 and hOT7T175 (a novel human G-protein-coupled receptors). Induces an increase in intracellular Ca2+ levels in CHO/h175 and CHO/AXOR12:Gqi5 cells and exhibits about 8-fold higher receptor binding affinity (Ki = 42 pM) compared to Metastin (Cat. No. 445885).
          Catalogue Number445888
          Brand Family Calbiochem®
          SynonymsKisspeptin-10, H-YNWNSFGLRF-NH₂, KiSS-1 (112-121)
          References
          ReferencesKotani, M., et al. 2001. J. Biol. Chem. 276, 34631.
          Ohtaki, T., et al. 2001. Nature 411, 613.
          Muir, A.I., et al. 2001. J. Biol. Chem. 276, 28969.
          Product Information
          ATP CompetitiveN
          FormWhite lyophilized solid
          FormulationSupplied as a trifluoroacetate salt.
          Hill FormulaC₆₃H₈₃N₁₇O₁₄
          Chemical formulaC₆₃H₈₃N₁₇O₁₄
          Hygroscopic Hygroscopic
          ReversibleN
          Applications
          ApplicationMetastin (45-54), CAS 374675-21-5, is a decapeptide that acts as a potent and selective agonist of AXOR12 and hOT7T175 (a novel human G-protein-coupled receptors).
          Biological Information
          Primary TargetAXOR12 and hOT7T175
          Primary Target K<sub>i</sub>42 pM for AXOR12 and hOT7T175
          Purity≥97% by HPLC
          Physicochemical Information
          Cell permeableN
          Peptide SequenceH-Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH₂
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 1 month at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          445888

          References

          Reference overview
          Kotani, M., et al. 2001. J. Biol. Chem. 276, 34631.
          Ohtaki, T., et al. 2001. Nature 411, 613.
          Muir, A.I., et al. 2001. J. Biol. Chem. 276, 28969.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision07-August-2008 RFH
          SynonymsKisspeptin-10, H-YNWNSFGLRF-NH₂, KiSS-1 (112-121)
          DescriptionA decapeptide with C-terminally amidated LRF-motif that acts as a potent and selective agonist of AXOR12 and hOT7T175 (a novel human G-protein-coupled receptor). More potent than the parent peptide. Induces an increase in intracellular Ca2+ levels in CHO/h175 and CHO/AXOR12:Gqi5 cells and exhibits about 8-fold higher receptor binding affinity (Ki = 42 pM, determined by competitive binding analysis) as compared to Metastin (Cat. No. 444885).
          FormWhite lyophilized solid
          FormulationSupplied as a trifluoroacetate salt.
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₆₃H₈₃N₁₇O₁₄
          Peptide SequenceH-Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH₂
          Purity≥97% by HPLC
          SolubilityDMSO (5 mg/ml)
          Storage -20°C
          Hygroscopic
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 1 month at -20°C.
          Toxicity Standard Handling
          ReferencesKotani, M., et al. 2001. J. Biol. Chem. 276, 34631.
          Ohtaki, T., et al. 2001. Nature 411, 613.
          Muir, A.I., et al. 2001. J. Biol. Chem. 276, 28969.