444800 Meloxicam - CAS 71125-38-7 - Calbiochem

444800
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₄H₁₃N₃O₄S₂ 71125-38-7

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      444800-100MG
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          Plastic ampoule 100 mg
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          Description
          OverviewA cell-permeable, non-steroidal anti-inflammatory drug (NSAID) of the oxicam family which preferentially inhibits the inducible isoform of COX-2 (IC50 = 4.7 µM) relative to COX-1 (IC50 = 36.6 µM). Also inhibits the growth of colorectal cancer cells in vitro.
          Catalogue Number444800
          Brand Family Calbiochem®
          Synonyms4-Hydroxy-2-methyl-N-(5-methyl-2-thiazoyl)-2H-1,2-benzothiazine-3-carboxamide-1,1-dioxide
          References
          ReferencesBlanco, F.J., et al. 1999. J. Rheumatol. 26, 1366.
          Davies, N.M., and Skjodt, N.M. 1999. Clin. Pharmacokinet. 36, 115.
          Goldman, A.P., et al. 1998. Carcinogenesis 19, 2195.
          Product Information
          CAS number71125-38-7
          ATP CompetitiveN
          FormOff-white solid
          Hill FormulaC₁₄H₁₃N₃O₄S₂
          Chemical formulaC₁₄H₁₃N₃O₄S₂
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetCOX-2
          Primary Target IC<sub>50</sub>4.7 µM, 36.6 µM against the inducible isoform of COX-2 relative to COX-1, respectively
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          444800

          References

          Reference overview
          Blanco, F.J., et al. 1999. J. Rheumatol. 26, 1366.
          Davies, N.M., and Skjodt, N.M. 1999. Clin. Pharmacokinet. 36, 115.
          Goldman, A.P., et al. 1998. Carcinogenesis 19, 2195.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision15-May-2008 RFH
          Synonyms4-Hydroxy-2-methyl-N-(5-methyl-2-thiazoyl)-2H-1,2-benzothiazine-3-carboxamide-1,1-dioxide
          DescriptionA cell-permeable, non-steroidal, anti-inflammatory drug (NSAID) of the oxicam family that preferentially inhibits the inducible isoform of cyclooxygenase-2 (COX-2; IC50 = 4.7 µM) relative to cyclooxygenase-1 (COX-1; IC50 = 36.6 µM). Also inhibits the growth of colorectal cancer cells in vitro.
          FormOff-white solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number71125-38-7
          Chemical formulaC₁₄H₁₃N₃O₄S₂
          Structure formulaStructure formula
          Purity≥98% by HPLC
          SolubilityDMSO (10 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for 3 months at -20°C.
          Toxicity Standard Handling
          Merck USA index14, 5826
          ReferencesBlanco, F.J., et al. 1999. J. Rheumatol. 26, 1366.
          Davies, N.M., and Skjodt, N.M. 1999. Clin. Pharmacokinet. 36, 115.
          Goldman, A.P., et al. 1998. Carcinogenesis 19, 2195.