504633 | MTEP Hydrochloride - CAS 1186195-60-7 - Calbiochem

504633
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₁H₈N₂SHCl 1186195-60-7

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      5.04633.0001
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          Glass bottle 10 mg
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          Description
          OverviewA non-competitive, potent antagonist highly selective for mGlu5 receptors (IC50 = 5 nM). Biologically active admitted orally or systematically. Widely used in assessing the functional roles of mGlu5 receptors in a variety of research areas, such as neuroprotection, depression, addiction, anxiety and stress related disorders, analgesia, locomotion, neural plasticity, and Parkinson's disease.
          Catalogue Number504633
          Brand Family Calbiochem®
          Synonyms3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine hydrochloride
          References
          ReferencesCosford, N., et al. 2003. J. Med. Chem. 46, 204.
          Varty, B., et al. 2005. Psychopharmacol. 179, 207.
          Domin, H., et al. 2006. Pharmacol. Reports. 58, 846.
          Johnston, Tom H., et al. 2010. J. Pharmacol. & Exp. Therapeutics 333, 865.
          McIldowie, M., et al. 2010. J. Pharm. Sci. 99, 234.
          Timmer, M., et al. 2012. Psychopharmacol. 221, 91.
          Wang, X., et al. 2013. Addict. Biol. 18, 40.
          Product Information
          CAS number1186195-60-7
          FormCream solid
          Hill FormulaC₁₁H₈N₂SHCl
          Chemical formulaC₁₁H₈N₂SHCl
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetmGlu₅ receptors
          Primary Target IC<sub>50</sub>5 nM
          Purity≥99% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          References

          Reference overview
          Cosford, N., et al. 2003. J. Med. Chem. 46, 204.
          Varty, B., et al. 2005. Psychopharmacol. 179, 207.
          Domin, H., et al. 2006. Pharmacol. Reports. 58, 846.
          Johnston, Tom H., et al. 2010. J. Pharmacol. & Exp. Therapeutics 333, 865.
          McIldowie, M., et al. 2010. J. Pharm. Sci. 99, 234.
          Timmer, M., et al. 2012. Psychopharmacol. 221, 91.
          Wang, X., et al. 2013. Addict. Biol. 18, 40.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision12-July-2013 JSW
          Synonyms3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine hydrochloride
          DescriptionA non-competitive, potent antagonist highly selective for mGlu5 receptors (IC50 = 5 nM). Biologically active admitted orally or systematically. Widely used in assessing the functional roles of mGlu5 receptors in a variety of research areas, such as neuroprotection, depression, addiction, anxiety and stress related disorders, analgesia, locomotion, neural plasticity, and Parkinson's disease.
          FormCream solid
          CAS number1186195-60-7
          Chemical formulaC₁₁H₈N₂SHCl
          Structure formulaStructure formula
          Purity≥99% by HPLC
          SolubilityH₂O (100 mM)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesCosford, N., et al. 2003. J. Med. Chem. 46, 204.
          Varty, B., et al. 2005. Psychopharmacol. 179, 207.
          Domin, H., et al. 2006. Pharmacol. Reports. 58, 846.
          Johnston, Tom H., et al. 2010. J. Pharmacol. & Exp. Therapeutics 333, 865.
          McIldowie, M., et al. 2010. J. Pharm. Sci. 99, 234.
          Timmer, M., et al. 2012. Psychopharmacol. 221, 91.
          Wang, X., et al. 2013. Addict. Biol. 18, 40.