531976 MPS1 Inhibitor III, AZ3146 - Calbiochem

531976
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₂₄H₃₂N₆O₃

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      5.31976.0001
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          Glass bottle 10 mg
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          Description
          OverviewA cell permeable purinone derivative that acts as a highly potent and selective inhibitor of monopolar spindle 1 kinase (MPS1; IC50 = ~35 nM). Inhibits the phosphorylation of full-length immunoprecipitated human MPS1 and exhibits minimal activity against a panel of 49 other protein kinases. Has much reduced activity against FAK, JNK1, JNK2, and KIT and does not affect the activity of mitotic-specific phosphoforms of Aurora B and BubR1. Induces a significant reduction in time to complete mitosis (from 90 min to 32 min) and causes abnormal mitosis where over 50% of cells enter anaphase without aligning their chromosomes.

          Please note that the molecular weight for this compound is batch-specific due to variable water content.
          Catalogue Number531976
          Brand Family Calbiochem®
          SynonymsAZ 3146, AZ-3146, Monopolar Spindle 1 Kinase Inhibitor, AZ3146
          References
          ReferencesHewitt, L., et al. 2010. Jour. Cell Biol. 190, 25.
          Product Information
          FormPurple powder
          Hill FormulaC₂₄H₃₂N₆O₃
          Chemical formulaC₂₄H₃₂N₆O₃
          ReversibleY
          Applications
          Biological Information
          Primary TargetMPS1
          Primary Target IC<sub>50</sub>~35 nM
          Purity≥97% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          MPS1 Inhibitor III, AZ3146 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          References

          Reference overview
          Hewitt, L., et al. 2010. Jour. Cell Biol. 190, 25.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision05-December-2014 JSW
          SynonymsAZ 3146, AZ-3146, Monopolar Spindle 1 Kinase Inhibitor, AZ3146
          DescriptionA cell permeable purinone derivative that acts as a highly potent and selective inhibitor of monopolar spindle 1 kinase (MPS1; IC50 = ~35 nM). Inhibits the phosphorylation of full-length immunoprecipitated human MPS1 and exhibits minimal activity against a panel of 49 other protein kinases. Has much reduced activity against FAK, JNK1, JNK2, and KIT and does not affect the activity of mitotic-specific phosphoforms of Aurora B and BubR1. Induces a significant reduction in time to complete mitosis (from 90 min to 32 min) and causes abnormal mitosis where over 50% of cells enter anaphase without aligning their chromosomes.
          FormPurple powder
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₂₄H₃₂N₆O₃
          Purity≥97% by HPLC
          SolubilityDMSO (5 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesHewitt, L., et al. 2010. Jour. Cell Biol. 190, 25.