454861 | MNK1 Inhibitor - CAS 522629-08-9 - Calbiochem

454861
Price could not be retrieved
Minimum Quantity needs to be mulitiple of
Upon Order Completion More Information
You Saved ()
 
Request Pricing
Limited AvailabilityLimited Availability
Stocked 
Discontinued
Limited Quantities Available
Available
    Remaining : Will advise
      Remaining : Will advise
      Will advise
      Contact Customer Service
      View Pricing & Availability
      Click To Print This Page

      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₁H₉FN₆ 522629-08-9

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      454861-5MG
      Retrieving availability...
      Limited AvailabilityLimited Availability
      Stocked 
      Discontinued
      Limited Quantities Available
      Available
        Remaining : Will advise
          Remaining : Will advise
          Will advise
          Contact Customer Service

          5 mg
          Retrieving price...
          Price could not be retrieved
          Minimum Quantity needs to be mulitiple of
          Upon Order Completion More Information
          You Saved ()
           
          Request Pricing
          Description
          OverviewA cell-permeable, reversible, and ATP-competitive pyrazolo-pyrimidine compound that acts as a selective inhibitor of mitogen-activated protein kinase-interacting kinase 1 (MNK1; IC50 = 2.2 µM) with no inhibitory activity against p38, JNK1, ERK1/2, PKC, or Src-like kinases. Effectively inhibits eIF4E phosphorylation (IC50 = 3 µM) by MNK1 in 293 human embryonic kidney cells and serves as a useful tool in studying MNK1-mediated cellular signaling.
          Catalogue Number454861
          Brand Family Calbiochem®
          Synonyms4-Amino-5-(4-fluoroanilino)-pyrazolo[3,4-d]pyrimidine, CGP 57380, MNK Inhibitor I, Mitogen-Activated Protein Kinase-Interacting Kinase Inhibitor I
          References
          ReferencesTopisirovic, I., et al. 2004. Cancer Res. 64, 8639.
          Worch, J., et al. 2004. Oncogene 23, 9162.
          Walsh, D., and Mohr, I. 2004. Genes Dev. 18, 660.
          Morley, S.J., and Naegele, S. 2002. J. Biol. Chem. 277, 32855.
          Knauf, U., et al. 2001. Mol. Cell. Biol. 21, 5500.
          Product Information
          CAS number522629-08-9
          ATP CompetitiveY
          FormOff-white solid
          Hill FormulaC₁₁H₉FN₆
          Chemical formulaC₁₁H₉FN₆
          ReversibleY
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetMitogen-activated protein kinase-interacting kinase 1 (MNK1)
          Primary Target IC<sub>50</sub>2.2 µM against mitogen-activated protein kinase-interacting kinase 1 (MNK1); 3 µM against eIF4E phosphorylation by MNK1 in 293 human embryonic kidney cells
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Toxic
          Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          454861

          References

          Reference overview
          Topisirovic, I., et al. 2004. Cancer Res. 64, 8639.
          Worch, J., et al. 2004. Oncogene 23, 9162.
          Walsh, D., and Mohr, I. 2004. Genes Dev. 18, 660.
          Morley, S.J., and Naegele, S. 2002. J. Biol. Chem. 277, 32855.
          Knauf, U., et al. 2001. Mol. Cell. Biol. 21, 5500.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision29-September-2012 JSW
          Synonyms4-Amino-5-(4-fluoroanilino)-pyrazolo[3,4-d]pyrimidine, CGP 57380, MNK Inhibitor I, Mitogen-Activated Protein Kinase-Interacting Kinase Inhibitor I
          DescriptionA cell-permeable, reversible, and ATP-competitive pyrazolo-pyrimidine compound that acts as a selective inhibitor of mitogen-activated protein kinase-interacting kinase 1 (MNK1; IC50 = 2.2 µM) with no inhibitory activity against p38, JNK1, ERK1/2, PKC, or Src-like kinases. Effectively inhibits eIF4E phosphorylation (IC50 = 3 µM) by MNK1 in 293 human embryonic kidney cells and serves as a useful tool in studying MNK1-mediated cellular signaling.
          FormOff-white solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number522629-08-9
          Chemical formulaC₁₁H₉FN₆
          Structure formulaStructure formula
          Purity≥98% by HPLC
          SolubilityDMSO (15 mg/ml) or Ethanol (5 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Toxic
          ReferencesTopisirovic, I., et al. 2004. Cancer Res. 64, 8639.
          Worch, J., et al. 2004. Oncogene 23, 9162.
          Walsh, D., and Mohr, I. 2004. Genes Dev. 18, 660.
          Morley, S.J., and Naegele, S. 2002. J. Biol. Chem. 277, 32855.
          Knauf, U., et al. 2001. Mol. Cell. Biol. 21, 5500.