534352 MNK Inhibitor IV, Mnk-I1 - Calbiochem

534352
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₂₂H₂₇F₂N₅O₂S

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      5.34352.0001
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          Glass bottle 10 mg
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          Description
          OverviewA cell-permeable thieno[2,3-d]pyrimidine compound that acts as a selective inhibitor of MAP kinase-interacting kinases 1 and 2 (Mnk1 and 2: IC50 = 23 and 16 nM for MNK1 and MNK2, respectively). Displays much reduced activity against several other protein kinases and does not affect the phosphorylation of ERK, Akt, mTORC1, and ribosomal S6 kinase. Shown to strongly inhibit eIF4E phosphorylation (~1 µM) and abolished the activity completely at higher concentration in MDA-MB-231 and SSC25 cancer cell (~ 1 µM). Shown to be much more effective Mnk inhibitor than CGP57380 (Cat. No. 454861). Reported to inhibit the migration of mouse embryonic fibroblasts and MDA-MB-231 and SCC25 cells, but does not affect their viability and proliferation.
          Catalogue Number534352
          Brand Family Calbiochem®
          SynonymsMNK1 Inhibitor, Mnk-I1
          References
          ReferencesBeggs, J.E., et al. 2015. Biochem. J. 467, 63.
          Product Information
          FormLight beige solid
          Hill FormulaC₂₂H₂₇F₂N₅O₂S
          Chemical formulaC₂₂H₂₇F₂N₅O₂S
          ReversibleY
          Applications
          Biological Information
          Primary TargetMNK
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          MNK Inhibitor IV, Mnk-I1 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          References

          Reference overview
          Beggs, J.E., et al. 2015. Biochem. J. 467, 63.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision28-July-2017 JSW
          SynonymsMNK1 Inhibitor, Mnk-I1
          DescriptionA cell-permeable thieno[2,3-d]pyrimidine compound that acts as a selective inhibitor of MAP kinase-interacting kinases 1 and 2 (Mnk1 and 2: IC50 = 23 and 16 nM for MNK1 and MNK2, respectively). Displays much reduced activity against several other protein kinases and does not affect the phosphorylation of ERK, Akt, mTORC1, and ribosomal S6 kinase. Shown to strongly inhibit eIF4E phosphorylation (~1 µM) and abolished the activity completely at higher concentration in MDA-MB-231 and SSC25 cancer cell (~ 1 µM). Shown to be much more effective Mnk inhibitor than CGP57380 (Cat. No. 454861). Reported to inhibit the migration of mouse embryonic fibroblasts and MDA-MB-231 and SCC25 cells, but does not affect their viability and proliferation.
          FormLight beige solid
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₂₂H₂₇F₂N₅O₂S
          Purity≥98% by HPLC
          SolubilityDMSO (25 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesBeggs, J.E., et al. 2015. Biochem. J. 467, 63.