504634 MMPIP - CAS 479077-02-6 - Calbiochem

504634
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₉H₁₅N₃O₃ 479077-02-6

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      5.04634.0001
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          Glass bottle 1 mg
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          Description
          OverviewA potent negative allosteric modulator highly selective for mGlu7 receptors (IC50 = 15 nM). No effect on other subtype mGlu receptors. Frequently used in studies of alcohol and cocaine addition, depression, anxiety and stress related disorders.
          Catalogue Number504634
          Brand Family Calbiochem®
          SynonymsMetabotropic Glutamate Receptor Type 7 Antagonist I, mGlu7 Antagonist I, mGluR7 Antagonist I, 6-(4-Methoxyphenyl)-5-methyl-3-(4-pyridinyl)-isoxazolo[ 4,5-c]pyridin-4(5H)-one
          References
          ReferencesPalucha-Poniewiera, A., et al. 2013. Behav. Brain Res. 238, 109.
          Bahi, A., et al. 2012. Addict. Biol. 17, 235.
          Harvey, H., et al. 2012. Pharmacol. Biochem. and Behav. 100, 775.
          Hikichi, H., et al. 2010. Eur. J. Pharmacol. 639, 106.
          Suzuki, X., et al. 2007. J. Pharmacol. Exp. Ther. 323, 147.
          Li, X., et al. 2009. Neuropsychopharmacology 34, 1783.
          Suzuki, G., et al. 2007. J. Pharmacol. Exp. Ther. 323, 147.
          Product Information
          CAS number479077-02-6
          FormWhite solid
          Hill FormulaC₁₉H₁₅N₃O₃
          Chemical formulaC₁₉H₁₅N₃O₃
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetmGlu₇ receptors
          Primary Target IC<sub>50</sub>15 nM
          Purity≥98% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          References

          Reference overview
          Palucha-Poniewiera, A., et al. 2013. Behav. Brain Res. 238, 109.
          Bahi, A., et al. 2012. Addict. Biol. 17, 235.
          Harvey, H., et al. 2012. Pharmacol. Biochem. and Behav. 100, 775.
          Hikichi, H., et al. 2010. Eur. J. Pharmacol. 639, 106.
          Suzuki, X., et al. 2007. J. Pharmacol. Exp. Ther. 323, 147.
          Li, X., et al. 2009. Neuropsychopharmacology 34, 1783.
          Suzuki, G., et al. 2007. J. Pharmacol. Exp. Ther. 323, 147.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision28-June-2013 JSW
          SynonymsMetabotropic Glutamate Receptor Type 7 Antagonist I, mGlu7 Antagonist I, mGluR7 Antagonist I, 6-(4-Methoxyphenyl)-5-methyl-3-(4-pyridinyl)-isoxazolo[ 4,5-c]pyridin-4(5H)-one
          DescriptionA potent negative allosteric modulator highly selective for mGlu7 receptors (IC50 = 15 nM). No effect on other subtype mGlu receptors. Frequently used in studies of alcohol and cocaine addition, depression, anxiety and stress related disorders.
          FormWhite solid
          CAS number479077-02-6
          Chemical formulaC₁₉H₁₅N₃O₃
          Structure formulaStructure formula
          Purity≥98% by HPLC
          SolubilityDMSO (10 mM)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesPalucha-Poniewiera, A., et al. 2013. Behav. Brain Res. 238, 109.
          Bahi, A., et al. 2012. Addict. Biol. 17, 235.
          Harvey, H., et al. 2012. Pharmacol. Biochem. and Behav. 100, 775.
          Hikichi, H., et al. 2010. Eur. J. Pharmacol. 639, 106.
          Suzuki, X., et al. 2007. J. Pharmacol. Exp. Ther. 323, 147.
          Li, X., et al. 2009. Neuropsychopharmacology 34, 1783.
          Suzuki, G., et al. 2007. J. Pharmacol. Exp. Ther. 323, 147.