444218 | MMP-3 Inhibitor I - Calbiochem

444218
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₂₇H₄₆N₁₀O₉S

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      444218-5MG
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          Plastic ampoule 5 mg
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          Description
          OverviewInhibits the matrix metalloproteinase MMP-3 (IC50 = 5 µM).
          Catalogue Number444218
          Brand Family Calbiochem®
          SynonymsAc-RCGVPD-NH₂, Stromelysin-1 Inhibitor
          References
          ReferencesFotouhi, N., et al. 1994. J. Biol. Chem. 269, 30227.
          Hanglow, A.C., et al. 1993. Agents Actions 39, C148.
          Product Information
          ATP CompetitiveN
          FormWhite solid
          FormulationSupplied as a trifluroacetate salt.
          Hill FormulaC₂₇H₄₆N₁₀O₉S
          Chemical formulaC₂₇H₄₆N₁₀O₉S
          Hygroscopic Hygroscopic
          ReversibleN
          Applications
          Biological Information
          Primary TargetMMP-3
          Primary Target IC<sub>50</sub>5 µM against MMP-3
          Purity≥90% by HPLC
          Physicochemical Information
          Cell permeableN
          Peptide SequenceAc-Arg-Cys-Gly-Val-Pro-Asp-NH₂
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing recosntitution, aliquot and freeze (-20°C). Stock solutions are stable for 1-2 weeks at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          444218

          References

          Reference overview
          Fotouhi, N., et al. 1994. J. Biol. Chem. 269, 30227.
          Hanglow, A.C., et al. 1993. Agents Actions 39, C148.

          Citations

          Title
        • Anthony R. White, et al. (2006) Degradation of the alzheimer disease amyloid -peptide by metal-dependent up-regulation of metalloprotease activity. journal of Biological Chemistry 281, 17670-17680.
        • Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision31-January-2008 JSW
          SynonymsAc-RCGVPD-NH₂, Stromelysin-1 Inhibitor
          DescriptionInhibits matrix metalloproteinase-3 (stromelysin) (IC50 = 5 µM). The inhibitor is based on a segment from the conserved region of the NH2-terminal propeptide domain.
          FormWhite solid
          FormulationSupplied as a trifluroacetate salt.
          Chemical formulaC₂₇H₄₆N₁₀O₉S
          Peptide SequenceAc-Arg-Cys-Gly-Val-Pro-Asp-NH₂
          Purity≥90% by HPLC
          SolubilityH₂O (1 mg/ml)
          Storage -20°C
          Hygroscopic
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing recosntitution, aliquot and freeze (-20°C). Stock solutions are stable for 1-2 weeks at -20°C.
          Toxicity Standard Handling
          ReferencesFotouhi, N., et al. 1994. J. Biol. Chem. 269, 30227.
          Hanglow, A.C., et al. 1993. Agents Actions 39, C148.
          Citation
        • Anthony R. White, et al. (2006) Degradation of the alzheimer disease amyloid -peptide by metal-dependent up-regulation of metalloprotease activity. journal of Biological Chemistry 281, 17670-17680.
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          Categories

          Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Proteases Inhibitors > Matrix Metalloproteinase (MMP) Inhibitors