444251 | MMP-2/MMP-9 Inhibitor III - Calbiochem

444251
Price could not be retrieved
Minimum Quantity needs to be mulitiple of
Upon Order Completion More Information
You Saved ()
 
Request Pricing
Limited AvailabilityLimited Availability
Stocked 
Discontinued
Limited Quantities Available
Available
    Remaining : Will advise
      Remaining : Will advise
      Will advise
      Contact Customer Service
      View Pricing & Availability
      Click To Print This Page

      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₅₂H₇₁N₁₃O₁₄S₂

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      444251-1MG
      Retrieving availability...
      Limited AvailabilityLimited Availability
      Stocked 
      Discontinued
      Limited Quantities Available
      Available
        Remaining : Will advise
          Remaining : Will advise
          Will advise
          Contact Customer Service

          Plastic ampoule 1 mg
          Retrieving price...
          Price could not be retrieved
          Minimum Quantity needs to be mulitiple of
          Upon Order Completion More Information
          You Saved ()
           
          Request Pricing
          Description
          OverviewA hydrophobic cyclic peptide that acts as a potent inhibitor of MMP-2 and MMP-9 (IC50 = 10 µM). Inhibits the migration of human endothelial cells and tumor cells, and prevents tumor growth and invasion in animal models. Also, phage that display this peptide specifically targets angiogenic blood vessels in vivo.
          Catalogue Number444251
          Brand Family Calbiochem®
          References
          ReferencesMedina, O.P., et al. 2001. Cancer Res. 61, 3978.
          Koivunen, E., et al. 1999. Nat. Biotechnology 17, 768.
          Product Information
          ATP CompetitiveN
          DeclarationSold under license of U.S. Patent 6,624,144.
          FormWhite lyophilized solid
          FormulationSupplied as a trifluoroacetate salt.
          Hill FormulaC₅₂H₇₁N₁₃O₁₄S₂
          Chemical formulaC₅₂H₇₁N₁₃O₁₄S₂
          Hygroscopic Hygroscopic
          ReversibleN
          Applications
          Biological Information
          Primary TargetMMP-2, MMP-9
          Primary Target IC<sub>50</sub>10 µM against MMP-2 and MMP-9
          Purity≥97% by HPLC
          Physicochemical Information
          Cell permeableN
          Peptide SequenceH-Cys¹-Thr-Thr-His-Trp-Gly-Phe-Thr-Leu-Cys¹⁰-OH (cyclic: 1→ 10)
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 2 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          444251

          References

          Reference overview
          Medina, O.P., et al. 2001. Cancer Res. 61, 3978.
          Koivunen, E., et al. 1999. Nat. Biotechnology 17, 768.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision06-August-2008 RFH
          DescriptionA cyclic peptide that acts as a potent inhibitor of MMP-2 (gelatinase A; IC50 = 10 µM) and MMP-9 (gelatinase B; IC50 = 10 µM). Inhibits the migration of human endothelial cells and tumor cells, and prevents tumor growth and invasion in animal models.
          FormWhite lyophilized solid
          FormulationSupplied as a trifluoroacetate salt.
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₅₂H₇₁N₁₃O₁₄S₂
          Peptide SequenceH-Cys¹-Thr-Thr-His-Trp-Gly-Phe-Thr-Leu-Cys¹⁰-OH (cyclic: 1→ 10)
          Purity≥97% by HPLC
          SolubilityH₂O (5 mg/ml)
          Storage -20°C
          Hygroscopic
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 2 months at -20°C.
          Toxicity Standard Handling
          ReferencesMedina, O.P., et al. 2001. Cancer Res. 61, 3978.
          Koivunen, E., et al. 1999. Nat. Biotechnology 17, 768.