444286 | MMP-2 Inhibitor II - CAS 869577-51-5 - Calbiochem

444286
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₆H₁₇NO₆S₂ 869577-51-5

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      444286-5MG
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          Plastic ampoule 5 mg
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          Description
          OverviewAn oxirane analog of SB-3CT, pMS (Cat. No. 444285) that acts as a selective, active site-binding, irreversible inhibitor of MMP-2 (Ki = 2.4 µM). Although less potent, it exhibits enhanced selectivity towards MMP-2 (Ki = 45 and 379 µM for MMP-1 and MMP-7, respectively) than SB-3CT, pMS.
          Catalogue Number444286
          Brand Family Calbiochem®
          Synonyms(4-(4-(Methanesulfonamido)phenoxy)phenylsulfonyl)methyloxirane
          References
          ReferencesIkejiri, M., et al. 2005. J. Biol. Chem. 280, 33992.
          Product Information
          CAS number869577-51-5
          FormWhite solid
          Hill FormulaC₁₆H₁₇NO₆S₂
          Chemical formulaC₁₆H₁₇NO₆S₂
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetMMP-2
          Primary Target K<sub>i</sub>2.4 µM
          Secondary targetMMP-2 (Ki = 45 and 379 µM for MMP-1 and MMP-7, respectively)
          Purity≥97% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Protect from Moisture Protect from moisture
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          444286

          References

          Reference overview
          Ikejiri, M., et al. 2005. J. Biol. Chem. 280, 33992.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision13-April-2011 RFH
          Synonyms(4-(4-(Methanesulfonamido)phenoxy)phenylsulfonyl)methyloxirane
          DescriptionAn oxirane analog of SB-3CT, pMS (Cat. No. 444285) that acts as a selective, active site-binding, irreversible inhibitor of MMP-2 (Ki = 2.4 µM). Although less potent, it exhibits enhanced selectivity towards MMP-2 (Ki = 45 and 379 µM for MMP-1 and MMP-7, respectively) than SB-3CT, pMS.
          FormWhite solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number869577-51-5
          Chemical formulaC₁₆H₁₇NO₆S₂
          Structure formulaStructure formula
          Purity≥97% by HPLC
          SolubilityDMSO (200 mg/ml)
          Storage -20°C
          Protect from moisture
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
          Toxicity Standard Handling
          ReferencesIkejiri, M., et al. 2005. J. Biol. Chem. 280, 33992.