475874 | MK571, Sodium Salt - CAS 115104-28-4 - Calbiochem

475874
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₆H₂₆ClN₂O₃S₂ • Na 115104-28-4

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      475874-5MG
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          Plastic ampoule 5 mg
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          Description
          OverviewA selective, competitive antagonist of leukotriene D4 (LTD4) (Ki = 2.1 nM for inhibition of [3H]LTD4 binding to human lung membranes). Also inhibits multidrug resistance-associated protein 1 (MRP1).
          Catalogue Number475874
          Brand Family Calbiochem®
          Synonyms(E)-3-[[[3-[2-(7-Chloro-2-quinolinyl)ethenyl]phenyl]-[[3-dimethylamino)-3-oxopropyl]thio]methyl]thio]-propanoic Acid, Sodium Salt, L 660711, Sodium Salt
          References
          ReferencesOlson, D.P., et al. 2001. Cytometry 46, 105.
          Van der Kolk, D.M., et al. 1998. Clin. Cancer Res. 4, 1727.
          Jones, T.R., et al. 1989. Can. J. Physiol. Pharmacol. 67, 17.
          Product Information
          CAS number115104-28-4
          ATP CompetitiveN
          FormOff-white solid
          Hill FormulaC₂₆H₂₆ClN₂O₃S₂ • Na
          Chemical formulaC₂₆H₂₆ClN₂O₃S₂ • Na
          Hygroscopic Hygroscopic
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetAntagonist of leukotriene D4 (LTD4)
          Primary Target K<sub>i</sub>2.1 nM for inhibition of [3H]LTD4 binding to human lung membranes
          Purity≥90% by HPLC
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Protect from Moisture Protect from moisture
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Aqueous stock solutions in are stable for up to 1 week at -20°C; DMSO stock solutions are stable for up to 6 months at -20°C. Acidic pH and heavy metals will accelerate decomposition.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          475874

          References

          Reference overview
          Olson, D.P., et al. 2001. Cytometry 46, 105.
          Van der Kolk, D.M., et al. 1998. Clin. Cancer Res. 4, 1727.
          Jones, T.R., et al. 1989. Can. J. Physiol. Pharmacol. 67, 17.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision11-August-2008 RFH
          Synonyms(E)-3-[[[3-[2-(7-Chloro-2-quinolinyl)ethenyl]phenyl]-[[3-dimethylamino)-3-oxopropyl]thio]methyl]thio]-propanoic Acid, Sodium Salt, L 660711, Sodium Salt
          DescriptionA selective, competitive antagonist of leukotriene D4 (LTD4) receptor (Ki = 2.1 nM for inhibition of [3H]LTD4 binding to human lung membranes). Also reported to inhibit multidrug resistance-associated protein 1 (MRP1).
          FormOff-white solid
          CAS number115104-28-4
          Chemical formulaC₂₆H₂₆ClN₂O₃S₂ • Na
          Structure formulaStructure formula
          Purity≥90% by HPLC
          SolubilityH₂O (200 mg/ml) or DMSO (10 mg/ml)
          Storage -20°C
          Hygroscopic
          Protect from moisture
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Aqueous stock solutions in are stable for up to 1 week at -20°C; DMSO stock solutions are stable for up to 6 months at -20°C. Acidic pH and heavy metals will accelerate decomposition.
          Toxicity Standard Handling
          ReferencesOlson, D.P., et al. 2001. Cytometry 46, 105.
          Van der Kolk, D.M., et al. 1998. Clin. Cancer Res. 4, 1727.
          Jones, T.R., et al. 1989. Can. J. Physiol. Pharmacol. 67, 17.