474787 | MG-132, ≥95% by HPLC - CAS 133407-82-6 - Calbiochem

474787
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₆H₄₁N₃O₅ 133407-82-6

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      474787-10MG
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      Stocked 
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      Available
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          Glass bottle 10 mg
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          Description
          OverviewPotent, reversible, and cell-permeable proteasome inhibitor (Ki = 4 nM). Reduces the degradation of ubiquitin-conjugated proteins in mammalian cells and permeable stains of yeast by the 26S complex without affecting its ATPase or isopeptidase activities. Activates c-Jun N-terminal kinase (JNK1) which initiates apoptosis. Inhibits NF-κB activation (IC50 = 3 µM). This material is ≥95% pure by HPLC. A material with ≥98% purity by HPLC (Cat. No. 474790) is also available. Also available as a 20 mM solution in DMSO (Cat. No. 474788).
          Catalogue Number474787
          Brand Family Calbiochem®
          SynonymsZ-Leu-Leu-Leu-CHO, Carbobenzoxy-L-leucyl-L-leucyl-L-leucinal, Proteasome Inhibitor XI
          References
          ReferencesSteinhilb, M.L., et al. 2001. J. Biol. Chem. 276, 4476.
          Meriin, A.B., et al. 1998. J. Biol. Chem. 273, 6373.
          Adams, J., and Stein, R. 1996. Ann. Rep. Med. Chem. 31, 279.
          Klafki, H.W., et al. 1996. J. Biol. Chem. 271, 2865.
          Lee, D.H., and Goldberg, A.L., 1996. J. Biol. Chem. 271, 27280.
          Wiertz, E.J., et al. 1996. Cell 84, 769.
          Jensen, T.J., et al. 1995. Cell 83, 129.
          Read, M.A., et al. 1995. Immunity 2, 493.
          Rock, K.L., et al. 1994. Cell 78, 761.
          Product Information
          CAS number133407-82-6
          FormWhite powder
          Hill FormulaC₂₆H₄₁N₃O₅
          Chemical formulaC₂₆H₄₁N₃O₅
          Structure formula ImageStructure formula Image
          Applications
          ApplicationMG-132, ≥95% by HPLC, CAS 133407-82-6, is a potent, reversible, and cell-permeable proteasome inhibitor (Ki = 4 nM).
          Biological Information
          Purity≥95% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          474787

          References

          Reference overview
          Steinhilb, M.L., et al. 2001. J. Biol. Chem. 276, 4476.
          Meriin, A.B., et al. 1998. J. Biol. Chem. 273, 6373.
          Adams, J., and Stein, R. 1996. Ann. Rep. Med. Chem. 31, 279.
          Klafki, H.W., et al. 1996. J. Biol. Chem. 271, 2865.
          Lee, D.H., and Goldberg, A.L., 1996. J. Biol. Chem. 271, 27280.
          Wiertz, E.J., et al. 1996. Cell 84, 769.
          Jensen, T.J., et al. 1995. Cell 83, 129.
          Read, M.A., et al. 1995. Immunity 2, 493.
          Rock, K.L., et al. 1994. Cell 78, 761.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision26-March-2012 JSW
          SynonymsZ-Leu-Leu-Leu-CHO, Carbobenzoxy-L-leucyl-L-leucyl-L-leucinal, Proteasome Inhibitor XI
          DescriptionPotent, reversible, and cell-permeable proteasome inhibitor (Ki = 4 nM). Reduces the degradation of ubiquitin-conjugated proteins in mammalian cells and permeable stains of yeast by the 26S complex without affecting its ATPase or isopeptidase activities. Activates c-Jun N-terminal kinase (JNK1) which initiates apoptosis. Inhibits NF-κB activation (IC50 = 3 µM). This material is ≥95% pure by HPLC. A material with ≥98% purity by HPLC (Cat. No. 474790) is also available.
          FormWhite powder
          Intert gas (Yes/No) Packaged under inert gas
          CAS number133407-82-6
          Chemical formulaC₂₆H₄₁N₃O₅
          Structure formulaStructure formula
          Purity≥95% by HPLC
          SolubilityDMSO (25 mg/ml) or Ethanol (25 mg/ml)
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesSteinhilb, M.L., et al. 2001. J. Biol. Chem. 276, 4476.
          Meriin, A.B., et al. 1998. J. Biol. Chem. 273, 6373.
          Adams, J., and Stein, R. 1996. Ann. Rep. Med. Chem. 31, 279.
          Klafki, H.W., et al. 1996. J. Biol. Chem. 271, 2865.
          Lee, D.H., and Goldberg, A.L., 1996. J. Biol. Chem. 271, 27280.
          Wiertz, E.J., et al. 1996. Cell 84, 769.
          Jensen, T.J., et al. 1995. Cell 83, 129.
          Read, M.A., et al. 1995. Immunity 2, 493.
          Rock, K.L., et al. 1994. Cell 78, 761.