444190 | MAP Kinase Inhibitor Set II - Calbiochem

444190
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      Overview

      Replacement Information

      Key Specifications Table

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      444190-1SET
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          Glass bottle 1 set
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          Description
          OverviewContains 5 mg of PD 98059 (Cat. No. 513000), 1 mg each of SB 203580 (Cat. No. 559389), and U0126 (Cat. No. 662005), and 1 mg of the negative control, SB 202474 (Cat. No. 559387).
          Catalogue Number444190
          Brand Family Calbiochem®
          References
          Product Information
          FormSolid
          Applications
          Biological Information
          Primary TargetMAP kinase
          Primary Target IC<sub>50</sub>2 µM
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze
          (-20°C).
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          444190
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision06-August-2008 RFH
          DescriptionThe Mitogen-activated protein kinases (MAP Kinases) are a group of protein serine/threonine kinases that are activated in response to a variety of extracellular stimuli and mediate signal transduction from the cell surface to the nucleus. MAP kinases, in combination with several other signaling pathways can differentially alter phosphorylation status of the transcription factors that is unique to a given signal from outside the cell. A controlled regulation of these cascades is involved in cell proliferation and differentiation, whereas an unregulated activation of these MAP kinases can result in oncogenesis. Three major types of MAP kinase cascades have been reported in mammalian cells that respond synergistically to different upstream signals. They are ERK1/ERK2 MAP kinases, the JNK/SAPK (c-Jun kinase/stress activated protein kinase), and the p38 kinase.

          The Calbiochem® MAP Kinase Inhibitor Set II contains 4 inhibitors with different MAP Kinase specificities for your convenience.
          FormSolid
          Intert gas (Yes/No) Packaged under inert gas
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze
          (-20°C).
          Toxicity Standard Handling