440025 | Luteolin - CAS 491-70-3 - Calbiochem

440025
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₅H₁₀O₆ 491-70-3

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      440025-5MG
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          Glass bottle 5 mg
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          Description
          OverviewAn antioxidant flavonoid and a free radical scavenger. Inhibits rat liver cytosolic glutathione S-transferase activity. Also shows cytotoxic effects on Raji lymphoma cells. Incubation of the non-tumor cell line C3H10T½CL8 with luteolin results in induction of p53 accumulation and apoptosis, with apoptosis occurring at the G2/M phase of the cell cycle. Also shown to inhibit TPL2 kinase.
          Catalogue Number440025
          Brand Family Calbiochem®
          Synonyms3ʹ,4ʹ,5,7-Tetrahydroxyflavone
          References
          ReferencesKim, J.E., et al. 2011. J. Pharmacol. Exp. Ther. in press.
          Korkina, L.G., and Afanasev, I.B. 1997. Adv. Pharmacol. 38, 151.
          Plaumann, B., et al. 1996. Oncogene 13, 1605.
          Ramanathan, R., et al. 1994. Free Radic. Biol. Med. 16, 43.
          Shimoi, L., et al. 1994. Carcinogenesis 15, 2669.
          Product Information
          CAS number491-70-3
          ATP CompetitiveN
          FormYellow solid
          Hill FormulaC₁₅H₁₀O₆
          Chemical formulaC₁₅H₁₀O₆
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary Targetrat liver cytosolic glutathione S-transferase activity
          Purity≥90% by HPLC
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSLK9275210
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 weeks at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          440025

          References

          Reference overview
          Kim, J.E., et al. 2011. J. Pharmacol. Exp. Ther. in press.
          Korkina, L.G., and Afanasev, I.B. 1997. Adv. Pharmacol. 38, 151.
          Plaumann, B., et al. 1996. Oncogene 13, 1605.
          Ramanathan, R., et al. 1994. Free Radic. Biol. Med. 16, 43.
          Shimoi, L., et al. 1994. Carcinogenesis 15, 2669.

          Brochure

          Title
          Nitric Oxide and Oxidative Stress Brochure
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision01-July-2011 JSW
          Synonyms3ʹ,4ʹ,5,7-Tetrahydroxyflavone
          DescriptionAn antioxidant flavonoid and a free radical scavenger. Inhibits rat liver cytosolic glutathione S-transferase activity. Also shows cytotoxic effects on Raji lymphoma cells. Incubation of the non-tumor cell line C3H10T1/2CL8 with luteolin results in induction of p53 accumulation and apoptosis, with apoptosis occurring at the G2/M phase of the cell cycle. Also shown to inhibit TPL2 kinase.
          FormYellow solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number491-70-3
          RTECSLK9275210
          Chemical formulaC₁₅H₁₀O₆
          Structure formulaStructure formula
          Purity≥90% by HPLC
          SolubilityAqueous alkaline solutions (1.4 mg/ml), DMSO (7 mg/ml), or Ethanol
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 weeks at -20°C.
          Toxicity Standard Handling
          Merck USA index14, 5614
          ReferencesKim, J.E., et al. 2011. J. Pharmacol. Exp. Ther. in press.
          Korkina, L.G., and Afanasev, I.B. 1997. Adv. Pharmacol. 38, 151.
          Plaumann, B., et al. 1996. Oncogene 13, 1605.
          Ramanathan, R., et al. 1994. Free Radic. Biol. Med. 16, 43.
          Shimoi, L., et al. 1994. Carcinogenesis 15, 2669.