428150 | Lavendustin A - CAS 125697-92-9 - Calbiochem

428150
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₁H₁₉NO₆ 125697-92-9

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      428150-1MG
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          Plastic ampoule 1 mg
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          Description
          OverviewA cell-permeable, reversible, and substrate competitive inhibitor of EGF receptor tyrosine kinase (IC50 = 11 nM) and p60c-src (IC50 = 500 nM) with little effect on protein kinase A or protein kinase C (IC50 > 200 µM). Also inhibits NMDA-stimulated cGMP production (IC50 = 30 nM). Exhibits anti-proliferative properties. Suppresses the angiogenic action of vascular endothelial growth factor (VEGF) in rats.
          Catalogue Number428150
          Brand Family Calbiochem®
          Synonyms5-Amino-[(N-2,5-dihydroxybenzyl)-Nʹ-2-hydroxybenzyl]salicylic Acid, RG14355
          References
          ReferencesHu, D.E., and Fan, T.-P. 1995. Br. J. Pharmacol. 114, 262.
          Rodriguez, J., et al. 1994. Neuropharmacology 33, 1267.
          Hsu, C.-Y., et al. 1991. J. Biol. Chem. 266, 21105.
          O’Dell, T.J., et al. 1991. Nature 353, 558; Onoda, T., et al. 1989. J. Nat. Prod. 52, 1252.
          Bishop, J.M. 1983. Annu. Rev. Biochem. 52, 307.
          Product Information
          CAS number125697-92-9
          ATP CompetitiveN
          FormOff-white solid
          Hill FormulaC₂₁H₁₉NO₆
          Chemical formulaC₂₁H₁₉NO₆
          ReversibleY
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetEGF receptor tyrosine kinase
          Primary Target IC<sub>50</sub>11 nM and 500 nM against EGF receptor tyrosine kinase and p60c-src, respectively
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          428150

          References

          Reference overview
          Hu, D.E., and Fan, T.-P. 1995. Br. J. Pharmacol. 114, 262.
          Rodriguez, J., et al. 1994. Neuropharmacology 33, 1267.
          Hsu, C.-Y., et al. 1991. J. Biol. Chem. 266, 21105.
          O’Dell, T.J., et al. 1991. Nature 353, 558; Onoda, T., et al. 1989. J. Nat. Prod. 52, 1252.
          Bishop, J.M. 1983. Annu. Rev. Biochem. 52, 307.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision12-January-2010 RFH
          Synonyms5-Amino-[(N-2,5-dihydroxybenzyl)-Nʹ-2-hydroxybenzyl]salicylic Acid, RG14355
          DescriptionA cell-permeable, reversible, substrate competitive, and potent inhibitor of EGF receptor tyrosine kinase (IC50 = 11 nM) and pp60c-src (IC50 = 500 nM) with little effect on protein kinase A or protein kinase C (IC50 >200 µM). Also inhibits NMDA-stimulated cGMP production (IC50 = 30 nM). Exhibits anti-proliferative properties. Suppresses the angiogenic action of vascular endothelial growth factor in rats.
          FormOff-white solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number125697-92-9
          Chemical formulaC₂₁H₁₉NO₆
          Structure formulaStructure formula
          Purity≥95% by HPLC
          SolubilityDMSO or Ethanol (10 mg/ml). Further dilute with aqueous buffer just prior to use.
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
          Toxicity Standard Handling
          ReferencesHu, D.E., and Fan, T.-P. 1995. Br. J. Pharmacol. 114, 262.
          Rodriguez, J., et al. 1994. Neuropharmacology 33, 1267.
          Hsu, C.-Y., et al. 1991. J. Biol. Chem. 266, 21105.
          O’Dell, T.J., et al. 1991. Nature 353, 558; Onoda, T., et al. 1989. J. Nat. Prod. 52, 1252.
          Bishop, J.M. 1983. Annu. Rev. Biochem. 52, 307.