428021 | Latrunculin A, Latrunculia magnifica - CAS 76343-93-6 - Calbiochem

428021
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₂H₃₁NO₅S 76343-93-6

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      428021-100UG
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          Plastic ampoule 100 μg
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          Description
          OverviewA cell-permeable marine toxin that disrupts microfilament organization in cultured cells by the formation of a 1:1 complex with monomeric G-actin (Kd = 200 nM). Also a potent inhibitor of microfilament-mediated processes in sperm, eggs, and embryos. A 1 mM (50 µg/119 µl) solution of Latrunculin A, Latrunculia magnifica Cat. No. 428026 in DMSO is also available.
          Catalogue Number428021
          Brand Family Calbiochem®
          References
          ReferencesAyscough, K.R., et al. 1997. J. Cell Biol. 137, 399.
          Spector, I., et al. 1989. Cell Motil. Cytoskeleton 13, 127.
          Coue, M., et al. 1987. FEBS Lett. 213, 316.
          Schatten, G., et al. 1986. Exp. Cell Res. 166, 191.
          Spector, I., et al. 1983. Science 219, 493.
          Product Information
          CAS number76343-93-6
          ATP CompetitiveN
          FormWhite solid
          Hill FormulaC₂₂H₃₁NO₅S
          Chemical formulaC₂₂H₃₁NO₅S
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetG-actin
          Primary Target IC<sub>50</sub>Kd = 200 nM in formation of a 1:1 complex with monomeric G-actin
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          R PhraseR: 20/21/22

          Harmful by inhalation, in contact with skin and if swallowed.
          S PhraseS: 36

          Wear suitable protective clothing.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Harmful
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          428021

          References

          Reference overview
          Ayscough, K.R., et al. 1997. J. Cell Biol. 137, 399.
          Spector, I., et al. 1989. Cell Motil. Cytoskeleton 13, 127.
          Coue, M., et al. 1987. FEBS Lett. 213, 316.
          Schatten, G., et al. 1986. Exp. Cell Res. 166, 191.
          Spector, I., et al. 1983. Science 219, 493.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision30-November-2012 JSW
          DescriptionA cell-permeable marine toxin from the Red Sea sponge Latrunculia magnifica that disrupts microfilament organization in cultured cells by the formation of a 1:1 complex with monomeric G-actin (Kd = 200 nM). Also a potent inhibitor of microfilament-mediated processes in sperm, eggs, and embryos.
          FormWhite solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number76343-93-6
          Chemical formulaC₂₂H₃₁NO₅S
          Structure formulaStructure formula
          Purity≥95% by HPLC
          SolubilityDMSO (100 mg/ml)
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Harmful
          Merck USA index14, 8378
          ReferencesAyscough, K.R., et al. 1997. J. Cell Biol. 137, 399.
          Spector, I., et al. 1989. Cell Motil. Cytoskeleton 13, 127.
          Coue, M., et al. 1987. FEBS Lett. 213, 316.
          Schatten, G., et al. 1986. Exp. Cell Res. 166, 191.
          Spector, I., et al. 1983. Science 219, 493.