506291 Lactimidomycin - CAS 134869-15-1 - Calbiochem

506291
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₆H₃₅NO₆ 134869-15-1

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      5.06291.0001
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          Glass bottle 0.2 mg
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          Description
          OverviewA glutarimide based 12-membered macrolide antibiotic with antifungal properties. Acts as a potent inhibitor of cell migration, cell proliferation, and protein synthesis (IC50 = 37.82 nM), but does not affect RNA synthesis even at high concentrations (IC50 > 10 µM). Acts as a potent inhibitor of translation and appears to block the first translocation step without affecting tRNA binding or peptide bond formation. It exhibits about 10-fold greater potency than cycloheximide (Cat. No. 239763 and 239764). Binds to the same site on the 60S ribosomal subunit with high affinity (Kd = 500 nM vs 15 µM for cycloheximide). Shown to extend the survival of mice bearing P388 lymphoma by blocking cell growth, however, it does not significantly affect non-tumorigenic MCF10A breast cell lines. Also shown to retard the growth of MDA MB231 cells in nude mice (~0.6 /mg/kg).
          Catalogue Number506291
          Brand Family Calbiochem®
          SynonymsLTM
          References
          ReferencesSchneider-Poetsch, T., et al. 2010. Nat. Chem. Biol. 6, 209.
          Micoine, K., et al. 2010. J. Am. Chem. Soc. 132, 14064.
          Ju, J., et al. 2009. J. Am. Chem. Soc. 131, 1370.
          Sugawara, K., et al. 1992. J. Antibiot. 45, 1433.
          Product Information
          CAS number134869-15-1
          FormWhite powder
          Hill FormulaC₂₆H₃₅NO₆
          Chemical formulaC₂₆H₃₅NO₆
          ReversibleY
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetRibosome
          Primary Target IC<sub>50</sub>37.8 nM, Kd
          Purity≥98% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          References

          Reference overview
          Schneider-Poetsch, T., et al. 2010. Nat. Chem. Biol. 6, 209.
          Micoine, K., et al. 2010. J. Am. Chem. Soc. 132, 14064.
          Ju, J., et al. 2009. J. Am. Chem. Soc. 131, 1370.
          Sugawara, K., et al. 1992. J. Antibiot. 45, 1433.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision20-September-2013 JSW
          SynonymsLTM
          DescriptionA glutarimide based 12-membered macrolide antibiotic with antifungal properties. Acts as a potent inhibitor of cell migration, cell proliferation, and protein synthesis (IC50 = 37.82 nM), but does not affect RNA synthesis even at high concentrations (IC50 > 10 µM). Acts as a potent inhibitor of translation and appears to block the first translocation step without affecting tRNA binding or peptide bond formation. It exhibits about 10-fold greater potency than cycloheximide (Cat. No. 239763 and 239764). Binds to the same site on the 60S ribosomal subunit with high affinity (Kd = 500 nM vs 15 µM for cycloheximide). Shown to extend the survival of mice bearing P388 lymphoma by blocking cell growth, however, it does not significantly affect non-tumorigenic MCF10A breast cell lines. Also shown to retard the growth of MDA MB231 cells in nude mice (~0.6 /mg/kg).
          FormWhite powder
          Intert gas (Yes/No) Packaged under inert gas
          CAS number134869-15-1
          Chemical formulaC₂₆H₃₅NO₆
          Structure formulaStructure formula
          Purity≥98% by HPLC
          SolubilityDMSO
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesSchneider-Poetsch, T., et al. 2010. Nat. Chem. Biol. 6, 209.
          Micoine, K., et al. 2010. J. Am. Chem. Soc. 132, 14064.
          Ju, J., et al. 2009. J. Am. Chem. Soc. 131, 1370.
          Sugawara, K., et al. 1992. J. Antibiot. 45, 1433.