440205 | LY 83583 - CAS 91300-60-6 - Calbiochem

440205
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₅H₁₀N₂O₂ 91300-60-6

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      440205-5MG
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          Plastic ampoule 5 mg
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          Description
          OverviewA cell-permeable, competitive inhibitor of soluble guanylate cyclase (IC50 = 2 µM). Lowers the production of cGMP levels in a wide range of tissues by blocking intracellular Ca2+ release, with negligible effect on cAMP levels. Inhibits nitric oxide-induced smooth muscle relaxation. Shown to inhibit interleukin-1-induced cGMP accumulation in cultured rat aortic vascular smooth muscle cells. Also inhibits neutrophil chemotaxis induced by NO donors.
          Catalogue Number440205
          Brand Family Calbiochem®
          Synonyms6-Anilino-5,8-quinolinequinone
          References
          ReferencesAdachi, R., et al. 2000. Int. J. Immunopharmacol. 22, 855.
          Kawada, T., et al. 1994. Gen. Pharmacol. 25, 1361.
          Beasley, D., et al. 1991. J. Clin. Invest. 87, 602.
          Pandol, S.J., et al. 1990. J. Biol. Chem. 265, 12846.
          Light, D.B., et al. 1989. Science 243, 383.
          Mulsch, A. 1988. J. Pharmacol. Exp. Ther. 247, 283.
          Fleisch, J.H., et al. 1984. J. Pharmacol. Exp. Ther. 229, 681.
          Product Information
          CAS number91300-60-6
          ATP CompetitiveN
          FormReddish purple solid
          Hill FormulaC₁₅H₁₀N₂O₂
          Chemical formulaC₁₅H₁₀N₂O₂
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary Targetsoluble guanylate cyclase
          Primary Target IC<sub>50</sub>2 µM against soluble guanylate cyclase
          Purity≥98% by TLC and HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          R PhraseR: 22-36/37/38-45-46-48

          Harmful if swallowed.
          Irritating to eyes, respiratory system and skin.
          May cause cancer.
          May cause heritable genetic damage.
          Danger of serious damage to health by prolonged exposure.
          S PhraseS: 22-26-36/37/39-45

          Do not breathe dust.
          In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
          Wear suitable protective clothing, gloves and eye/face protection.
          In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Harmful & Carcinogenic / Teratogenic
          Storage +2°C to +8°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 1 month at 4°C or up to 6 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          440205

          References

          Reference overview
          Adachi, R., et al. 2000. Int. J. Immunopharmacol. 22, 855.
          Kawada, T., et al. 1994. Gen. Pharmacol. 25, 1361.
          Beasley, D., et al. 1991. J. Clin. Invest. 87, 602.
          Pandol, S.J., et al. 1990. J. Biol. Chem. 265, 12846.
          Light, D.B., et al. 1989. Science 243, 383.
          Mulsch, A. 1988. J. Pharmacol. Exp. Ther. 247, 283.
          Fleisch, J.H., et al. 1984. J. Pharmacol. Exp. Ther. 229, 681.

          Brochure

          Title
          Calcium Metabolism and Related Products Brochure
          Nitric Oxide and Oxidative Stress Brochure
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision06-August-2008 RFH
          Synonyms6-Anilino-5,8-quinolinequinone
          DescriptionA cell-permeable, competitive inhibitor of soluble guanylate cyclase (IC50 = 2 µM). Lowers the production of cGMP levels in a wide range of tissues by blocking intracellular Ca2+ release, with negligible effect on cAMP levels. Inhibits nitric oxide-induced smooth muscle relaxation. Shown to inhibit interleukin-1-induced cGMP accumulation in cultured rat aortic vascular smooth muscle cells.
          FormReddish purple solid
          CAS number91300-60-6
          Chemical formulaC₁₅H₁₀N₂O₂
          Structure formulaStructure formula
          Purity≥98% by TLC and HPLC
          SolubilityAcetone or Ethanol (3 mg/ml)
          Storage +2°C to +8°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 1 month at 4°C or up to 6 months at -20°C.
          Toxicity Harmful & Carcinogenic / Teratogenic
          ReferencesAdachi, R., et al. 2000. Int. J. Immunopharmacol. 22, 855.
          Kawada, T., et al. 1994. Gen. Pharmacol. 25, 1361.
          Beasley, D., et al. 1991. J. Clin. Invest. 87, 602.
          Pandol, S.J., et al. 1990. J. Biol. Chem. 265, 12846.
          Light, D.B., et al. 1989. Science 243, 383.
          Mulsch, A. 1988. J. Pharmacol. Exp. Ther. 247, 283.
          Fleisch, J.H., et al. 1984. J. Pharmacol. Exp. Ther. 229, 681.