508150 | LY 344864 Hydrochloride - CAS 186544-26-3 - Calbiochem

508150
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₁H₂₂FN₃O·HCl 186544-26-3

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      5.08150.0001
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          Glass bottle 10 mg
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          Description
          OverviewA selective, brain penetrant, full agonist for the 5-HT1F receptor (pKi = 8.2). It possesses little affinity for the 56 other serotonergic and non-serotonergic neuronal binding sites examined. When examined for its ability to inhibit forskolin-induced cyclic AMP accumulation in cells stably transfected with human 5-HT1F receptors, LY344864 was shown to be a full agonist producing an effect similar in magnitude to serotonin itself. Suitable for both in vitro and in vivo applications and its effects are often reversed with the 5-HT1B/1D antagonist GR 127935 (Cat. No. 508014)
          Catalogue Number508150
          Brand Family Calbiochem®
          Synonyms5-HT1F Serotonin Receptor Agonist, LY 344864, LY344864, LY-344864
          References
          ReferencesAmrutkar, D. V. et al. 2012. Pain. 153, 830.
          Phebus, L. A. et al. 1997. Life Sci. 61, 2117.
          Product Information
          CAS number186544-26-3
          FormWhite solid
          Hill FormulaC₂₁H₂₂FN₃O·HCl
          Chemical formulaC₂₁H₂₂FN₃O·HCl
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary Target5-HT1F
          Purity≥98% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          References

          Reference overview
          Amrutkar, D. V. et al. 2012. Pain. 153, 830.
          Phebus, L. A. et al. 1997. Life Sci. 61, 2117.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision31-October-2013 JSW
          Synonyms5-HT1F Serotonin Receptor Agonist, LY 344864, LY344864, LY-344864
          DescriptionA selective, brain penetrant, full agonist for the 5-HT1F receptor (pKi = 8.2). It possesses little affinity for the 56 other serotonergic and non-serotonergic neuronal binding sites examined. When examined for its ability to inhibit forskolin-induced cyclic AMP accumulation in cells stably transfected with human 5-HT1F receptors, LY344864 was shown to be a full agonist producing an effect similar in magnitude to serotonin itself. Suitable for both in vitro and in vivo applications and its effects are often reversed with the 5-HT1B/1D antagonist GR 127935 (Cat. No. 508014)
          FormWhite solid
          CAS number186544-26-3
          Chemical formulaC₂₁H₂₂FN₃O·HCl
          Structure formulaStructure formula
          Purity≥98% by HPLC
          SolubilityDMSO (100 mM) or H₂O (10 mM)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesAmrutkar, D. V. et al. 2012. Pain. 153, 830.
          Phebus, L. A. et al. 1997. Life Sci. 61, 2117.