505770 | LSD1 Inhibitor VI, Cpd 2d - Calbiochem

505770
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₄₇H₆₈N₁₂

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      5.05770.0001
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          Glass bottle 5 mg
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          Description
          OverviewA cell-permeable polyamine derivative that acts as an inhibitor of lysine-specific demethylase-1 (LSD1, KDM1) and increases levels of mono- and di-methylated histone H3K4, H3K9 proteins in acute myeloid leukemia (AML) cancer cells in a dose-dependent manner. Shown to cause significant growth inhibition in different AML cell lines (HL-60, KG1a, HNT-34, and ML-1 cells) at low micromolar concentrations (5 to 10 µM) over a period of 96 hours. Induces re-expression of cancer suppressing E-caherin gene and CDH-1 mRNA in tumor cells (˜10 µM). Also, displays anti-trypanosomal properties and inhibits trypanothione reductase activity (IC50 = 950 nM) in Trypanosoma brucei brucei.

          Please note that the molecular weight for this compound is batch-specific due to variable water content.
          Catalogue Number505770
          Brand Family Calbiochem®
          Synonyms1,15-bis{N5-[3,3-(diphenyl)propyl]-N1-biguanido}-4,12-diazapentadecane
          References
          ReferencesMurray-Stewart, T., et al. 2013, Amino Acids 44, in press.
          Bi, X. et al. 2006, Bioorg. Med. Chem. Lett. 16,3229.
          Product Information
          FormOff-white solid
          Hill FormulaC₄₇H₆₈N₁₂
          Chemical formulaC₄₇H₆₈N₁₂
          Hygroscopic Hygroscopic
          Applications
          Biological Information
          Primary TargetLSD1
          Purity≥98% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          References

          Reference overview
          Murray-Stewart, T., et al. 2013, Amino Acids 44, in press.
          Bi, X. et al. 2006, Bioorg. Med. Chem. Lett. 16,3229.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision05-September-2014 JSW
          Synonyms1,15-bis{N5-[3,3-(diphenyl)propyl]-N1-biguanido}-4,12-diazapentadecane
          DescriptionA cell-permeable polyamine derivative that acts as an inhibitor of lysine-specific demethylase-1 (LSD1, KDM1) and increases levels of mono- and di-methylated histone H3K4, H3K9 proteins in acute myeloid leukemia (AML) cancer cells in a dose-dependent manner. Shown to cause significant growth inhibition in different AML cell lines (HL-60, KG1a, HNT-34, and ML-1 cells) at low micromolar concentrations (5 to 10 µM) over a period of 96 hours. Induces re-expression of cancer suppressing E-caherin gene and CDH-1 mRNA in tumor cells (˜10 µM). Also, displays anti-trypanosomal properties and inhibits trypanothione reductase activity (IC50 = 950 nM) in Trypanosoma brucei brucei.
          FormOff-white solid
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₄₇H₆₈N₁₂
          Purity≥98% by HPLC
          SolubilityDMSO (100 mg/ml)
          Storage +2°C to +8°C
          Hygroscopic
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesMurray-Stewart, T., et al. 2013, Amino Acids 44, in press.
          Bi, X. et al. 2006, Bioorg. Med. Chem. Lett. 16,3229.