524644 L-α-Phosphatidyl-D-myo-inositol-4,5-bisphosphate, Triammonium Salt, Porcine Brain - CAS 383907-42-4 - Calbiochem

524644
Price could not be retrieved
Minimum Quantity needs to be mulitiple of
Upon Order Completion More Information
You Saved ()
 
Request Pricing
Limited AvailabilityLimited Availability
Stocked 
Discontinued
Limited Quantities Available
Available
    Remaining : Will advise
      Remaining : Will advise
      Will advise
      Contact Customer Service
      Contact Customer Service
      View Pricing & Availability
      Click To Print This Page

      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₄₇H₈₂O₁₉P₃ · 3NH₄ 383907-42-4

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      524644-100UG
      Retrieving availability...
      Limited AvailabilityLimited Availability
      Stocked 
      Discontinued
      Limited Quantities Available
      Available
        Remaining : Will advise
          Remaining : Will advise
          Will advise
          Contact Customer Service
          Contact Customer Service

          Plastic ampoule 100 μg
          Retrieving price...
          Price could not be retrieved
          Minimum Quantity needs to be mulitiple of
          Upon Order Completion More Information
          You Saved ()
           
          Request Pricing
          524644-1MG
          Retrieving availability...
          Limited AvailabilityLimited Availability
          Stocked 
          Discontinued
          Limited Quantities Available
          Available
            Remaining : Will advise
              Remaining : Will advise
              Will advise
              Contact Customer Service
              Contact Customer Service

              Plastic ampoule 1 mg
              Retrieving price...
              Price could not be retrieved
              Minimum Quantity needs to be mulitiple of
              Upon Order Completion More Information
              You Saved ()
               
              Request Pricing
              Description
              OverviewA component of membrane-bound receptors in association with phospholipase C (PLC). Potently stimulates brain phospholipase D (PLD) activity in vitro. Has been shown to activate protein kinase C (PKC) in the presence of phosphatidylserine and Ca2+. Antagonist of ATP-sensitive potassium (KATP) channels when applied to inside-out membrane patches.
              Catalogue Number524644
              Brand Family Calbiochem®
              SynonymsPIP₂
              References
              ReferencesBaukrowitz, T., et al. 1998. Science 282, 1141.
              Shyng, S.-L., and Nichols, C.G. 1998. Science 282, 1138.
              Mazzotti, G., et al. 1995. J. Histochem. Cytochem. 43, 181.
              Liscovitch, M., et al. 1994. J. Biol. Chem. 269, 21403.
              Chauhan, A., et al. 1991. Biochem. Biophys. Res. Commun. 175, 852.
              Williamson, J.R. 1986. Hypertension 8, 140.
              Berridge, M.J., and Irvine, R.F. 1984. Nature 312, 315.
              Product Information
              CAS number383907-42-4
              ATP CompetitiveN
              FormWhite to off-white solid
              Hill FormulaC₄₇H₈₂O₁₉P₃ · 3NH₄
              Chemical formulaC₄₇H₈₂O₁₉P₃ · 3NH₄
              Hygroscopic Hygroscopic
              ReversibleN
              Structure formula ImageStructure formula Image
              Applications
              Biological Information
              Primary TargetBrain phospholipase D (PLD)
              Purity≥98% by TLC
              Physicochemical Information
              Cell permeableN
              Dimensions
              Materials Information
              Toxicological Information
              Safety Information according to GHS
              Safety Information
              R PhraseR: 36/37/38

              Irritating to eyes, respiratory system and skin.
              S PhraseS: 26-36

              In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
              Wear suitable protective clothing.
              Product Usage Statements
              Storage and Shipping Information
              Ship Code Dry Ice Only
              Toxicity Irritant
              Storage ≤ -70°C
              Protect from Light Protect from light
              Hygroscopic Hygroscopic
              Do not freeze Ok to freeze
              Special InstructionsFollowing reconstitution in H₂O, store in the refrigerator (4°C). Do not freeze aqueous solutions. Following reconstitution in chloroform, aliquot and freeze (-20°C). Aqueous stock solutions are stable for up to 2 days at 4°C. Chloroform stock solutions are stable for up to 1 month at -20°C.
              Packaging Information
              Packaged under inert gas Packaged under inert gas
              Transport Information
              Supplemental Information
              Specifications

              Documentation

              SDS

              Title

              Safety Data Sheet (SDS) 

              Certificates of Analysis

              TitleLot Number
              524644

              References

              Reference overview
              Baukrowitz, T., et al. 1998. Science 282, 1141.
              Shyng, S.-L., and Nichols, C.G. 1998. Science 282, 1138.
              Mazzotti, G., et al. 1995. J. Histochem. Cytochem. 43, 181.
              Liscovitch, M., et al. 1994. J. Biol. Chem. 269, 21403.
              Chauhan, A., et al. 1991. Biochem. Biophys. Res. Commun. 175, 852.
              Williamson, J.R. 1986. Hypertension 8, 140.
              Berridge, M.J., and Irvine, R.F. 1984. Nature 312, 315.

              Brochure

              Title
              Calcium Metabolism and Related Products Brochure
              Data Sheet

              Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

              Revision03-August-2015 JSW
              SynonymsPIP₂
              DescriptionA component of membrane-bound receptors in association with phospholipase C. Hydrolysis of PIP2 yields IP3 and diacylglycerol, causing the release of intracellular Ca2+ and activation of protein kinase C. Potently stimulates phospholipase D activity in vitro in brain tissue. A substrate for PI 3-kinase. Antagonist of ATP inhibtion of ATP-sensitive potassium (KATP) channels when applied to inside-out membrane patches.

              Note: This product is not to be used for animal treatment, in vivo research or in any other contact procedure with livestock.
              FormWhite to off-white solid
              Intert gas (Yes/No) Packaged under inert gas
              CAS number383907-42-4
              Chemical formulaC₄₇H₈₂O₁₉P₃ · 3NH₄
              Structure formulaStructure formula
              Purity≥98% by TLC
              SolubilityCHCl₃ (50 mg/ml) or H₂O (10 mg/ml)
              Storage ≤ -70°C
              Hygroscopic
              Protect from light
              Do Not Freeze Ok to freeze
              Special InstructionsFollowing reconstitution in H₂O, store in the refrigerator (4°C). Do not freeze aqueous solutions. Following reconstitution in chloroform, aliquot and freeze (-20°C). Aqueous stock solutions are stable for up to 2 days at 4°C. Chloroform stock solutions are stable for up to 1 month at -20°C.
              Toxicity Irritant
              ReferencesBaukrowitz, T., et al. 1998. Science 282, 1141.
              Shyng, S.-L., and Nichols, C.G. 1998. Science 282, 1138.
              Mazzotti, G., et al. 1995. J. Histochem. Cytochem. 43, 181.
              Liscovitch, M., et al. 1994. J. Biol. Chem. 269, 21403.
              Chauhan, A., et al. 1991. Biochem. Biophys. Res. Commun. 175, 852.
              Williamson, J.R. 1986. Hypertension 8, 140.
              Berridge, M.J., and Irvine, R.F. 1984. Nature 312, 315.